TY - JOUR
T1 - Nocardiopsins C and D and nocardiopyrone A : new polyketides from an Australian marine-derived Nocardiopsis sp.
AU - Raju, Ritesh
AU - Piggott, Andrew M.
AU - Quezada, Michelle
AU - Capon, Robert J.
PY - 2013
Y1 - 2013
N2 - A Nocardiopsis sp. (CMB-M0232) recovered from marine sediment collected off the coast of South Molle Island, Queensland, Australia, yielded two new examples of rare prolinyl-macrolactam polyketides, nocardiopsins C (1) and D (2), a new highly substituted α-pyrone polyketide, nocardiopyrone A (3), and the previously reported macrolide polyketides nocardiopsins A (4) and B (5). Structures were assigned on the basis of detailed spectroscopic analysis, degradation, and chemical derivatization. PCR amplification of CMB-M0232 genomic DNA revealed the presence of type I and type II polyketide synthase and nonribosomal peptide synthase domains.
AB - A Nocardiopsis sp. (CMB-M0232) recovered from marine sediment collected off the coast of South Molle Island, Queensland, Australia, yielded two new examples of rare prolinyl-macrolactam polyketides, nocardiopsins C (1) and D (2), a new highly substituted α-pyrone polyketide, nocardiopyrone A (3), and the previously reported macrolide polyketides nocardiopsins A (4) and B (5). Structures were assigned on the basis of detailed spectroscopic analysis, degradation, and chemical derivatization. PCR amplification of CMB-M0232 genomic DNA revealed the presence of type I and type II polyketide synthase and nonribosomal peptide synthase domains.
UR - http://handle.uws.edu.au:8081/1959.7/549026
U2 - 10.1016/j.tet.2012.10.104
DO - 10.1016/j.tet.2012.10.104
M3 - Article
SN - 1464-5416
VL - 69
SP - 692
EP - 698
JO - Tetrahedron
JF - Tetrahedron
IS - 2
ER -