Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

N. Parameswaran; R. C. A. Thompson; N. Sundar; S. Pan; M. Johnson; N. C. Smith; M. E. Grigg

doi:10.1016/j.ijpara.2010.02.008

Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

N. Parameswaran, R. C. A. Thompson, N. Sundar, S. Pan, M. Johnson, N. C. Smith, M. E. Grigg

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia’s isolation may have favoured the persistence of non-archetypal ancestral genotypes.

Original language	English
Pages (from-to)	635-640
Number of pages	6
Journal	International Journal for Parasitology
Volume	40
Issue number	6
DOIs	https://doi.org/10.1016/j.ijpara.2010.02.008
Publication status	Published - 2010

Keywords

Australia
Toxoplasma gondii
genotype
geographic isolation
marsupials
parasites

Access to Document

10.1016/j.ijpara.2010.02.008

Cite this

@article{31ec851596a14213b7160c208f5c5167,

title = "Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia",

abstract = "Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia{\textquoteright}s isolation may have favoured the persistence of non-archetypal ancestral genotypes.",

keywords = "Australia, Toxoplasma gondii, genotype, geographic isolation, marsupials, parasites",

author = "N. Parameswaran and Thompson, {R. C. A.} and N. Sundar and S. Pan and M. Johnson and Smith, {N. C.} and Grigg, {M. E.}",

year = "2010",

doi = "10.1016/j.ijpara.2010.02.008",

language = "English",

volume = "40",

pages = "635--640",

journal = "International Journal for Parasitology",

issn = "0020-7519",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

AU - Parameswaran, N.

AU - Thompson, R. C. A.

AU - Sundar, N.

AU - Pan, S.

AU - Johnson, M.

AU - Smith, N. C.

AU - Grigg, M. E.

PY - 2010

Y1 - 2010

N2 - Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia’s isolation may have favoured the persistence of non-archetypal ancestral genotypes.

AB - Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia’s isolation may have favoured the persistence of non-archetypal ancestral genotypes.

KW - Australia

KW - Toxoplasma gondii

KW - genotype

KW - geographic isolation

KW - marsupials

KW - parasites

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:40005

U2 - 10.1016/j.ijpara.2010.02.008

DO - 10.1016/j.ijpara.2010.02.008

M3 - Article

SN - 0020-7519

VL - 40

SP - 635

EP - 640

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 6

ER -

Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this