NT-proBNP changes in patients with ascites during large volume paracentesis

Vi Nguyen; Rob Zielinski; Paul Harnett; Katherine Miller; Henry Chan; Nikitha Vootakuru; Priya Acharya; Montaha Khan; Oliver Gibbs; Sarika Gupta; Anjla Devi; Shani Phillips; Jacob George; David van der Poorten

doi:10.1155/2013/959474

NT-proBNP changes in patients with ascites during large volume paracentesis

Vi Nguyen, Rob Zielinski, Paul Harnett, Katherine Miller, Henry Chan, Nikitha Vootakuru, Priya Acharya, Montaha Khan, Oliver Gibbs, Sarika Gupta, Anjla Devi, Shani Phillips, Jacob George, David van der Poorten

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NTproBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (𝑃 = 0.05 and 𝑃 = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (𝑃 < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NTproBNP during LVP occur in patients with cirrhosis but notmalignancy, and only comorbid CCF appeared to predict such changes.

Original language	English
Article number	959474
Number of pages	7
Journal	ISRN Hepatology
Volume	2013
DOIs	https://doi.org/10.1155/2013/959474
Publication status	Published - 2013

Open Access - Access Right Statement

© 2013 Vi Nguyen et al. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

patients
paracentesis
ascites
serum

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10.1155/2013/959474

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@article{8a947659d01f4f4589643cdb06181c3a,

title = "NT-proBNP changes in patients with ascites during large volume paracentesis",

abstract = "N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NTproBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (𝑃 = 0.05 and 𝑃 = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (𝑃 < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NTproBNP during LVP occur in patients with cirrhosis but notmalignancy, and only comorbid CCF appeared to predict such changes.",

keywords = "patients, paracentesis, ascites, serum",

author = "Vi Nguyen and Rob Zielinski and Paul Harnett and Katherine Miller and Henry Chan and Nikitha Vootakuru and Priya Acharya and Montaha Khan and Oliver Gibbs and Sarika Gupta and Anjla Devi and Shani Phillips and Jacob George and Poorten, {David van der}",

year = "2013",

doi = "10.1155/2013/959474",

language = "English",

volume = "2013",

journal = "ISRN Hepatology",

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publisher = "Hindawi",

}

TY - JOUR

T1 - NT-proBNP changes in patients with ascites during large volume paracentesis

AU - Nguyen, Vi

AU - Zielinski, Rob

AU - Harnett, Paul

AU - Miller, Katherine

AU - Chan, Henry

AU - Vootakuru, Nikitha

AU - Acharya, Priya

AU - Khan, Montaha

AU - Gibbs, Oliver

AU - Gupta, Sarika

AU - Devi, Anjla

AU - Phillips, Shani

AU - George, Jacob

AU - Poorten, David van der

PY - 2013

Y1 - 2013

N2 - N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NTproBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (𝑃 = 0.05 and 𝑃 = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (𝑃 < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NTproBNP during LVP occur in patients with cirrhosis but notmalignancy, and only comorbid CCF appeared to predict such changes.

AB - N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NTproBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (𝑃 = 0.05 and 𝑃 = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (𝑃 < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NTproBNP during LVP occur in patients with cirrhosis but notmalignancy, and only comorbid CCF appeared to predict such changes.

KW - patients

KW - paracentesis

KW - ascites

KW - serum

UR - http://hdl.handle.net/1959.7/uws:53401

U2 - 10.1155/2013/959474

DO - 10.1155/2013/959474

M3 - Article

SN - 2314-4041

VL - 2013

JO - ISRN Hepatology

JF - ISRN Hepatology

M1 - 959474

ER -

NT-proBNP changes in patients with ascites during large volume paracentesis

Abstract

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