Obesity and metabolic syndrome

Sunil K. Panchal, Maharshi Bhaswant, Lindsay Brown

Research output: Chapter in Book / Conference PaperChapter

Abstract

Animals have contributed significantly to the understanding of human biochemistry, physiology, pathophysiology, and pharmacology. Different models have been developed, characterized, and then successfully used for the development of preventive measures or cures for human diseases. One of the important human conditions is metabolic syndrome, and this can be successfully mimicked in rodents. We have already described the major characteristics of the most common rodent models used in metabolic syndrome research [1]. Here, we will revisit the important animal models for metabolic syndrome research and then discuss the limited translatability of these models to human trials.
Original languageEnglish
Title of host publicationIn Vivo Models for Drug Discovery
EditorsJose M. Vela, Rafael Maldonado, Michel Hamon
Place of PublicationGermany
PublisherWiley-VCH
Pages333-348
Number of pages16
ISBN (Electronic)9783527679362
ISBN (Print)9783527333288
DOIs
Publication statusPublished - 2014

Keywords

  • diabetes
  • diseases
  • metabolic syndrome
  • obesity

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