OfftargetFinder : a web tool for species-specific RNAi design

R. T. Good; T. Varghese; J. R. Golz; D. A. Russell; A. Papanicolaou; O. Edwards; C. Robin

doi:10.1093/bioinformatics/btv747

OfftargetFinder : a web tool for species-specific RNAi design

R. T. Good, T. Varghese, J. R. Golz, D. A. Russell, A. Papanicolaou, O. Edwards, C. Robin

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Motivation: RNA interference (RNAi) technology is being developed as a weapon for pest insect control. To maximize the specificity that such an approach affords we have developed a bioinformatics web tool that searches the ever-growing arthropod transcriptome databases so that pest-specific RNAi sequences can be identified. This will help technology developers finesse the design of RNAi sequences and suggests which non-target species should be assessed in the risk assessment process.

Original language	English
Pages (from-to)	1232-1234
Number of pages	3
Journal	Bioinformatics
Volume	32
Issue number	8
DOIs	https://doi.org/10.1093/bioinformatics/btv747
Publication status	Published - 2016

Keywords

RNA interference
insect pests
control

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10.1093/bioinformatics/btv747

Cite this

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abstract = "Motivation: RNA interference (RNAi) technology is being developed as a weapon for pest insect control. To maximize the specificity that such an approach affords we have developed a bioinformatics web tool that searches the ever-growing arthropod transcriptome databases so that pest-specific RNAi sequences can be identified. This will help technology developers finesse the design of RNAi sequences and suggests which non-target species should be assessed in the risk assessment process.",

keywords = "RNA interference, insect pests, control",

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AU - Good, R. T.

AU - Varghese, T.

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AU - Russell, D. A.

AU - Papanicolaou, A.

AU - Edwards, O.

AU - Robin, C.

PY - 2016

Y1 - 2016

N2 - Motivation: RNA interference (RNAi) technology is being developed as a weapon for pest insect control. To maximize the specificity that such an approach affords we have developed a bioinformatics web tool that searches the ever-growing arthropod transcriptome databases so that pest-specific RNAi sequences can be identified. This will help technology developers finesse the design of RNAi sequences and suggests which non-target species should be assessed in the risk assessment process.

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KW - RNA interference

KW - insect pests

KW - control

UR - http://handle.uws.edu.au:8081/1959.7/uws:35762

U2 - 10.1093/bioinformatics/btv747

DO - 10.1093/bioinformatics/btv747

M3 - Article

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JO - Bioinformatics

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OfftargetFinder : a web tool for species-specific RNAi design

Abstract

Keywords

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