Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation

Tianruo Guo; Nigel H. Lovell; David Tsai; Perry Twyford; Shelley Fried; John W. Morley; Gregg J. Suaning; Socrates Dokos

doi:10.1109/NER.2015.7146607

Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation

Tianruo Guo, Nigel H. Lovell, David Tsai, Perry Twyford, Shelley Fried, John W. Morley, Gregg J. Suaning, Socrates Dokos

School of Medicine

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

3 Citations (Scopus)

Abstract

A retinal ganglion cell (RGC) model based on accurate biophysics and detailed representations of cell morphologies was used to understand how these cells respond to electrical stimulation over a wide range of frequencies, spanning 50-2000 pulses per second (PPS). Our modeling results and associated in vitro data both suggest the usefulness of high stimulation frequency in effectively modulating the activity of RGCs. This model can be used for optimizing varied extracellular stimulus profiles, and to assist in the design of sophisticated stimulation strategies for clinical visual neuroprostheses.

Original language	English
Title of host publication	Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, April 22-24, 2015, Montpellier, France
Publisher	IEEE
Pages	252-255
Number of pages	4
ISBN (Print)	9781467363891
DOIs	https://doi.org/10.1109/NER.2015.7146607
Publication status	Published - 2015
Event	International IEEE EMBS Conference on Neural Engineering - Duration: 22 Apr 2015 → …

Publication series

Name
ISSN (Print)	1948-3546

Conference

Conference	International IEEE EMBS Conference on Neural Engineering
Period	22/04/15 → …

Keywords

electric stimulation
neurons
retinal ganglion cells

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10.1109/NER.2015.7146607

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Guo, T., Lovell, N. H., Tsai, D., Twyford, P., Fried, S., Morley, J. W., Suaning, G. J., & Dokos, S. (2015). Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation. In Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, April 22-24, 2015, Montpellier, France (pp. 252-255). IEEE. https://doi.org/10.1109/NER.2015.7146607

@inproceedings{c833b51a6ca140ae875134569ab9036e,

title = "Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation",

abstract = "A retinal ganglion cell (RGC) model based on accurate biophysics and detailed representations of cell morphologies was used to understand how these cells respond to electrical stimulation over a wide range of frequencies, spanning 50-2000 pulses per second (PPS). Our modeling results and associated in vitro data both suggest the usefulness of high stimulation frequency in effectively modulating the activity of RGCs. This model can be used for optimizing varied extracellular stimulus profiles, and to assist in the design of sophisticated stimulation strategies for clinical visual neuroprostheses.",

keywords = "electric stimulation, neurons, retinal ganglion cells",

author = "Tianruo Guo and Lovell, {Nigel H.} and David Tsai and Perry Twyford and Shelley Fried and Morley, {John W.} and Suaning, {Gregg J.} and Socrates Dokos",

year = "2015",

doi = "10.1109/NER.2015.7146607",

language = "English",

isbn = "9781467363891",

publisher = "IEEE",

pages = "252--255",

booktitle = "Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, April 22-24, 2015, Montpellier, France",

note = "International IEEE EMBS Conference on Neural Engineering ; Conference date: 22-04-2015",

}

Guo, T, Lovell, NH, Tsai, D, Twyford, P, Fried, S, Morley, JW, Suaning, GJ & Dokos, S 2015, Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation. in Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, April 22-24, 2015, Montpellier, France. IEEE, pp. 252-255, International IEEE EMBS Conference on Neural Engineering, 22/04/15. https://doi.org/10.1109/NER.2015.7146607

Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation. / Guo, Tianruo; Lovell, Nigel H.; Tsai, David et al.
Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, April 22-24, 2015, Montpellier, France. IEEE, 2015. p. 252-255.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

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T1 - Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation

AU - Guo, Tianruo

AU - Lovell, Nigel H.

AU - Tsai, David

AU - Twyford, Perry

AU - Fried, Shelley

AU - Morley, John W.

AU - Suaning, Gregg J.

AU - Dokos, Socrates

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N2 - A retinal ganglion cell (RGC) model based on accurate biophysics and detailed representations of cell morphologies was used to understand how these cells respond to electrical stimulation over a wide range of frequencies, spanning 50-2000 pulses per second (PPS). Our modeling results and associated in vitro data both suggest the usefulness of high stimulation frequency in effectively modulating the activity of RGCs. This model can be used for optimizing varied extracellular stimulus profiles, and to assist in the design of sophisticated stimulation strategies for clinical visual neuroprostheses.

AB - A retinal ganglion cell (RGC) model based on accurate biophysics and detailed representations of cell morphologies was used to understand how these cells respond to electrical stimulation over a wide range of frequencies, spanning 50-2000 pulses per second (PPS). Our modeling results and associated in vitro data both suggest the usefulness of high stimulation frequency in effectively modulating the activity of RGCs. This model can be used for optimizing varied extracellular stimulus profiles, and to assist in the design of sophisticated stimulation strategies for clinical visual neuroprostheses.

KW - electric stimulation

KW - neurons

KW - retinal ganglion cells

UR - http://handle.uws.edu.au:8081/1959.7/uws:31919

UR - http://neuro.embs.org/2015/

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DO - 10.1109/NER.2015.7146607

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BT - Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, April 22-24, 2015, Montpellier, France

PB - IEEE

T2 - International IEEE EMBS Conference on Neural Engineering

Y2 - 22 April 2015

ER -

Guo T, Lovell NH, Tsai D, Twyford P, Fried S, Morley JW et al. Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation. In Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, April 22-24, 2015, Montpellier, France. IEEE. 2015. p. 252-255 doi: 10.1109/NER.2015.7146607

Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation

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