TY - JOUR
T1 - Organoid technology : current standing and future perspectives
AU - Shariati, Laleh
AU - Esmaeili, Yasaman
AU - Haghjooy Javanmard, Shaghayegh
AU - Bidram, Elham
AU - Amini, Abbas
PY - 2021
Y1 - 2021
N2 - Organoids are powerful systems to facilitate the study of individuals’ disorders and personalized treatments. Likewise, emerging this technology has improved the chance of translatability of drugs for pre-clinical therapies and mimicking the complexity of organs, while it proposes numerous approaches for human disease modeling, tissue engineering, drug development, diagnosis, and regenerative medicine. In this review, we outline the past/present organoid technology and summarize its faithful applications, then, we discuss the challenges and limitations encountered by 3D organoids. In the end, we offer the human organoids as basic mechanistic infrastructure for “human modelling” systems to prescribe personalized medicines.
AB - Organoids are powerful systems to facilitate the study of individuals’ disorders and personalized treatments. Likewise, emerging this technology has improved the chance of translatability of drugs for pre-clinical therapies and mimicking the complexity of organs, while it proposes numerous approaches for human disease modeling, tissue engineering, drug development, diagnosis, and regenerative medicine. In this review, we outline the past/present organoid technology and summarize its faithful applications, then, we discuss the challenges and limitations encountered by 3D organoids. In the end, we offer the human organoids as basic mechanistic infrastructure for “human modelling” systems to prescribe personalized medicines.
UR - http://hdl.handle.net/1959.7/uws:59386
UR - https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3379
U2 - 10.1002/stem.3379
DO - 10.1002/stem.3379
M3 - Article
SN - 1066-5099
VL - 39
SP - 1625
EP - 1649
JO - Stem Cells
JF - Stem Cells
IS - 12
ER -