Abstract
We demonstrate that asbestos particles can initiate protein oxidation, especially when provided with co-reactants such as hydrogen peroxide. This can lead to protein fragmentation, as shown with albumin as target. Sub- mitochondrial particles are also oxidised by asbestos-derived radicals, leading to lipid peroxidation. These oxidations parallel the capacity of the particles to hydroxylate benzoate in the presence of hydrogen peroxide, but in some cases can be initiated by the particles alone. The surface availability of metals influences the extent of reaction of the different particles, and the removal of metals from the particles by acid washing decreases their reactivity in these systems. Such reactions may be important in the toxicity of asbestos.
| Original language | English |
|---|---|
| Pages (from-to) | 163-169 |
| Number of pages | 7 |
| Journal | Pathogenesis |
| Volume | 1 |
| Issue number | 3 |
| Publication status | Published - 1999 |
| Externally published | Yes |
Keywords
- Asbestos
- Lipid oxidation
- Metals
- Protein oxidation