TY - JOUR
T1 - Oxidative stress and HIF-1α modulate hypoxic ventilatory responses after hypoxic training on athletes
AU - Pialoux, Vincent
AU - Brugniaux, Julien V.
AU - Fellmann, Nicole
AU - Richalet, Jean-Paul
AU - Robach, Paul
AU - Schmitt, Laurent
AU - Coudert, Jean
AU - Mounier, Remi
PY - 2009
Y1 - 2009
N2 - We investigated the strength of the association between oxidative stress, hypoxia inducible factor 1 (HIF-1α) and acute hypoxic ventilatory response (AHVR) after hypoxic training in elite runners. Six elite runners were submitted to 18-day of "living high-training low" (LHTL) and six performed the same training in normoxia. AHVR was measured during an acute hypoxic test before and after training. Plasma levels of protein oxidation (AOPP), malondialdehydes and (HIF-1α) mRNA in the leukocytes were measured before and after the acute hypoxic test. LHTL increased AHVR and amplified the responses of HIF-1α mRNA and AOPP (Δ AOPP) to the acute hypoxic test. Furthermore, between PRE and POST, the changes in Δ AOPP were correlated with the changes in AHVR (r = 0.69, P = 0.01). The ventilatory acclimatization to hypoxia occurring in athletes after LHTL seems to be modulated by oxidative stress. Furthermore, LHTL induced a higher sensitivity of HIF-1α mRNA to acute hypoxia in elite athletes.
AB - We investigated the strength of the association between oxidative stress, hypoxia inducible factor 1 (HIF-1α) and acute hypoxic ventilatory response (AHVR) after hypoxic training in elite runners. Six elite runners were submitted to 18-day of "living high-training low" (LHTL) and six performed the same training in normoxia. AHVR was measured during an acute hypoxic test before and after training. Plasma levels of protein oxidation (AOPP), malondialdehydes and (HIF-1α) mRNA in the leukocytes were measured before and after the acute hypoxic test. LHTL increased AHVR and amplified the responses of HIF-1α mRNA and AOPP (Δ AOPP) to the acute hypoxic test. Furthermore, between PRE and POST, the changes in Δ AOPP were correlated with the changes in AHVR (r = 0.69, P = 0.01). The ventilatory acclimatization to hypoxia occurring in athletes after LHTL seems to be modulated by oxidative stress. Furthermore, LHTL induced a higher sensitivity of HIF-1α mRNA to acute hypoxia in elite athletes.
KW - athletes
KW - exercise
KW - hypoxia
KW - oxidative stress
UR - http://handle.uws.edu.au:8081/1959.7/uws:36680
U2 - 10.1016/j.resp.2009.04.012
DO - 10.1016/j.resp.2009.04.012
M3 - Article
SN - 1569-9048
VL - 167
SP - 217
EP - 220
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 2
ER -