P53 expression in laryngeal carcinoma

Guy Boag; C. Soon Lee; Dora Charalambous; Jürgen Rode

doi:10.3109/00313029309090866

P53 expression in laryngeal carcinoma

Guy Boag, C. Soon Lee, Dora Charalambous, Jürgen Rode

University of Melbourne

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The expression of the nuclear phosphoprotein, p53, was studied in 21 cases of squamous cell carcinoma of the larynx and 16 benign laryngeal lesions using the polyclonal rabbit antibody,CM1 (Novocastra Laboratories Ltd). Fourteen of the carcinomas showed nuclear staining whereas only one of the benign lesions exhibited presence of the protein. This suggests that, as with squamous cell carcinoma of the lung, p53 plays a role in the development of malignant disease of the larynx.

Original language	English
Pages (from-to)	394-397
Number of pages	4
Journal	Pathology
Volume	25
Issue number	4
DOIs	https://doi.org/10.3109/00313029309090866
Publication status	Published - 1993
Externally published	Yes

Keywords

Laryngeal cancers
P53
Tumor suppressor gene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/00313029309090866

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title = "P53 expression in laryngeal carcinoma",

abstract = "The expression of the nuclear phosphoprotein, p53, was studied in 21 cases of squamous cell carcinoma of the larynx and 16 benign laryngeal lesions using the polyclonal rabbit antibody,CM1 (Novocastra Laboratories Ltd). Fourteen of the carcinomas showed nuclear staining whereas only one of the benign lesions exhibited presence of the protein. This suggests that, as with squamous cell carcinoma of the lung, p53 plays a role in the development of malignant disease of the larynx.",

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AU - Boag, Guy

AU - Lee, C. Soon

AU - Charalambous, Dora

AU - Rode, Jürgen

PY - 1993

Y1 - 1993

N2 - The expression of the nuclear phosphoprotein, p53, was studied in 21 cases of squamous cell carcinoma of the larynx and 16 benign laryngeal lesions using the polyclonal rabbit antibody,CM1 (Novocastra Laboratories Ltd). Fourteen of the carcinomas showed nuclear staining whereas only one of the benign lesions exhibited presence of the protein. This suggests that, as with squamous cell carcinoma of the lung, p53 plays a role in the development of malignant disease of the larynx.

AB - The expression of the nuclear phosphoprotein, p53, was studied in 21 cases of squamous cell carcinoma of the larynx and 16 benign laryngeal lesions using the polyclonal rabbit antibody,CM1 (Novocastra Laboratories Ltd). Fourteen of the carcinomas showed nuclear staining whereas only one of the benign lesions exhibited presence of the protein. This suggests that, as with squamous cell carcinoma of the lung, p53 plays a role in the development of malignant disease of the larynx.

KW - Laryngeal cancers

KW - P53

KW - Tumor suppressor gene

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DO - 10.3109/00313029309090866

M3 - Article

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VL - 25

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JO - Pathology

JF - Pathology

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ER -

P53 expression in laryngeal carcinoma

Abstract

Keywords

UN SDGs

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