Pathophysiology of major depression by clinical stages

Ana Cecília de Menezes Galvão; Raíssa Nobrega Almeida; Geovan Menezes de Sousa; Mario André Leocadio-Miguel; Fernanda Palhano-Fontes; Dráulio Barros de Araujo; Bruno Lobão-Soares; João Paulo Maia-de-Oliveira; Emerson Arcoverde Nunes; Jaime Eduardo Cecilio Hallak; Felipe Barreto Schuch; Jerome Sarris; Nicole Leite Galvão-Coelho

doi:10.3389/fpsyg.2021.641779

Pathophysiology of major depression by clinical stages

Ana Cecília de Menezes Galvão
, Raíssa Nobrega Almeida
, Geovan Menezes de Sousa
, Mario André Leocadio-Miguel
, Fernanda Palhano-Fontes
, Dráulio Barros de Araujo
, Bruno Lobão-Soares
, João Paulo Maia-de-Oliveira
, Emerson Arcoverde Nunes
, Jaime Eduardo Cecilio Hallak
, Felipe Barreto Schuch
, Jerome Sarris
, Nicole Leite Galvão-Coelho

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression.

Original language	English
Article number	641779
Number of pages	12
Journal	Frontiers in Psychology
Volume	12
DOIs	https://doi.org/10.3389/fpsyg.2021.641779
Publication status	Published - 5 Aug 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 de Menezes Galvão, Almeida, de Sousa, Leocadio-Miguel, Palhano-Fontes, de Araujo, Lobão-Soares, Maia-de-Oliveira, Nunes, Hallak, Schuch, Sarris and Galvão-Coelho.

Open Access - Access Right Statement

© 2021 de Menezes Galvão, Almeida, de Sousa, Leocadio-Miguel, Palhano-Fontes, de Araujo, Lobão-Soares, Maia-de-Oliveira, Nunes, Hallak, Schuch, Sarris and Galvão-Coelho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Access to Document

10.3389/fpsyg.2021.641779

Cite this

Galvão, A. C. D. M., Almeida, R. N., de Sousa, G. M., Leocadio-Miguel, M. A., Palhano-Fontes, F., Araujo, D. B. D., Lobão-Soares, B., Maia-de-Oliveira, J. P., Nunes, E. A., Hallak, J. E. C., Schuch, F. B., Sarris, J., & Galvão-Coelho, N. L. (2021). Pathophysiology of major depression by clinical stages. Frontiers in Psychology, 12, Article 641779. https://doi.org/10.3389/fpsyg.2021.641779

@article{683e304255494e9caa663c9b27b2e951,

title = "Pathophysiology of major depression by clinical stages",

abstract = "The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression.",

author = "Galv{\~a}o, \{Ana Cec{\'i}lia de Menezes\} and Almeida, \{Ra{\'i}ssa Nobrega\} and \{de Sousa\}, \{Geovan Menezes\} and Leocadio-Miguel, \{Mario Andr{\'e}\} and Fernanda Palhano-Fontes and Araujo, \{Dr{\'a}ulio Barros de\} and Bruno Lob{\~a}o-Soares and Maia-de-Oliveira, \{Jo{\~a}o Paulo\} and Nunes, \{Emerson Arcoverde\} and Hallak, \{Jaime Eduardo Cecilio\} and Schuch, \{Felipe Barreto\} and Jerome Sarris and Galv{\~a}o-Coelho, \{Nicole Leite\}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 de Menezes Galv{\~a}o, Almeida, de Sousa, Leocadio-Miguel, Palhano-Fontes, de Araujo, Lob{\~a}o-Soares, Maia-de-Oliveira, Nunes, Hallak, Schuch, Sarris and Galv{\~a}o-Coelho.",

year = "2021",

month = aug,

day = "5",

doi = "10.3389/fpsyg.2021.641779",

language = "English",

volume = "12",

journal = "Frontiers in Psychology",

issn = "1664-1078",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Pathophysiology of major depression by clinical stages

AU - Galvão, Ana Cecília de Menezes

AU - Almeida, Raíssa Nobrega

AU - de Sousa, Geovan Menezes

AU - Leocadio-Miguel, Mario André

AU - Palhano-Fontes, Fernanda

AU - Araujo, Dráulio Barros de

AU - Lobão-Soares, Bruno

AU - Maia-de-Oliveira, João Paulo

AU - Nunes, Emerson Arcoverde

AU - Hallak, Jaime Eduardo Cecilio

AU - Schuch, Felipe Barreto

AU - Sarris, Jerome

AU - Galvão-Coelho, Nicole Leite

N1 - Publisher Copyright: © Copyright © 2021 de Menezes Galvão, Almeida, de Sousa, Leocadio-Miguel, Palhano-Fontes, de Araujo, Lobão-Soares, Maia-de-Oliveira, Nunes, Hallak, Schuch, Sarris and Galvão-Coelho.

PY - 2021/8/5

Y1 - 2021/8/5

N2 - The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression.

AB - The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression.

UR - https://hdl.handle.net/1959.7/uws:63392

U2 - 10.3389/fpsyg.2021.641779

DO - 10.3389/fpsyg.2021.641779

M3 - Article

SN - 1664-1078

VL - 12

JO - Frontiers in Psychology

JF - Frontiers in Psychology

M1 - 641779

ER -

Pathophysiology of major depression by clinical stages

Abstract

Bibliographical note

Open Access - Access Right Statement

Access to Document

Other files and links

Fingerprint

Cite this