PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent : a biodistribution study

Afsaneh Lahooti; S. Sarkar; H. S. Rad; A. Gholami; S. Nosrati; R. N. Muller; S. Laurent; C. Grüttner; P. Geramifar; H. Yousefnia; M. Mazidi; S. Shanehsazzadeh

doi:10.1007/s10967-016-5058-0

PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent : a biodistribution study

Afsaneh Lahooti, S. Sarkar, H. S. Rad, A. Gholami, S. Nosrati, R. N. Muller, S. Laurent, C. Grüttner, P. Geramifar, H. Yousefnia, M. Mazidi, S. Shanehsazzadeh

Western Sydney University

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.

Original language	English
Pages (from-to)	769-774
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	311
Issue number	1
DOIs	https://doi.org/10.1007/s10967-016-5058-0
Publication status	Published - 2017

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10.1007/s10967-016-5058-0

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Lahooti, A., Sarkar, S., Rad, H. S., Gholami, A., Nosrati, S., Muller, R. N., Laurent, S., Grüttner, C., Geramifar, P., Yousefnia, H., Mazidi, M., & Shanehsazzadeh, S. (2017). PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent : a biodistribution study. Journal of Radioanalytical and Nuclear Chemistry, 311(1), 769-774. https://doi.org/10.1007/s10967-016-5058-0

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title = "PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent : a biodistribution study",

abstract = "The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.",

author = "Afsaneh Lahooti and S. Sarkar and Rad, {H. S.} and A. Gholami and S. Nosrati and Muller, {R. N.} and S. Laurent and C. Gr{\"u}ttner and P. Geramifar and H. Yousefnia and M. Mazidi and S. Shanehsazzadeh",

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doi = "10.1007/s10967-016-5058-0",

language = "English",

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Lahooti, A, Sarkar, S, Rad, HS, Gholami, A, Nosrati, S, Muller, RN, Laurent, S, Grüttner, C, Geramifar, P, Yousefnia, H, Mazidi, M & Shanehsazzadeh, S 2017, 'PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent : a biodistribution study', Journal of Radioanalytical and Nuclear Chemistry, vol. 311, no. 1, pp. 769-774. https://doi.org/10.1007/s10967-016-5058-0

TY - JOUR

T1 - PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent : a biodistribution study

AU - Lahooti, Afsaneh

AU - Sarkar, S.

AU - Rad, H. S.

AU - Gholami, A.

AU - Nosrati, S.

AU - Muller, R. N.

AU - Laurent, S.

AU - Grüttner, C.

AU - Geramifar, P.

AU - Yousefnia, H.

AU - Mazidi, M.

AU - Shanehsazzadeh, S.

PY - 2017

Y1 - 2017

N2 - The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.

AB - The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.

UR - https://hdl.handle.net/1959.7/uws:76301

U2 - 10.1007/s10967-016-5058-0

DO - 10.1007/s10967-016-5058-0

M3 - Article

SN - 0236-5731

VL - 311

SP - 769

EP - 774

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 1

ER -

PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent : a biodistribution study

Abstract

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