Perfluoropolyether corneal onlays: Adhesive development

T. C. Hughes; G. Y.N. Chan; M. D.M. Evans; G. Johnson; T. P.T. Le; G. McFarland; K. M. McLean; X. Nguyen; D. F. Sweeney; J. S. Wilkie; R. Z. Xie

Perfluoropolyether corneal onlays: Adhesive development

T. C. Hughes, G. Y.N. Chan, M. D.M. Evans, G. Johnson, T. P.T. Le, G. McFarland, K. M. McLean, X. Nguyen, D. F. Sweeney, J. S. Wilkie, R. Z. Xie

Research output: Chapter in Book / Conference Paper › Conference Paper

Abstract

The development of surgical adhesives, that show potential for adhering synthetic polyfluoropolyether (PEPF) lenticules to a debrided corneal surface, was reported. The PFPE lenticules were prepared by photo-polymerization of the PFPE macromonomers dispersed in a microemulsion. The PFPE lenticules were surface modified by a radio frequency glow discharge (rfgd) plasma polymerization of acetaldehyde, to which collagen was covealently coupled using reductive amination. Lenticules were shown to adhere and sustained epithelial overgrowth was demonstrated for up to 92 days. It was demonstrated that collagen coated PFPE can support epithelial overgrowth in vivo when implanted in the cornea using a superficial keratotomy.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress, 17 -21 May 2004, Sydney, Australia
Pages	1653
Number of pages	1
Publication status	Published - 2004
Externally published	Yes
Event	World Biomaterials Congress - Sydney, Australia Duration: 17 May 2004 → 21 May 2004 Conference number: 7th

Conference

Conference	World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	17/05/04 → 21/05/04

Cite this

@inproceedings{c9677138351f43b2b13ae3afa958d861,

title = "Perfluoropolyether corneal onlays: Adhesive development",

abstract = "The development of surgical adhesives, that show potential for adhering synthetic polyfluoropolyether (PEPF) lenticules to a debrided corneal surface, was reported. The PFPE lenticules were prepared by photo-polymerization of the PFPE macromonomers dispersed in a microemulsion. The PFPE lenticules were surface modified by a radio frequency glow discharge (rfgd) plasma polymerization of acetaldehyde, to which collagen was covealently coupled using reductive amination. Lenticules were shown to adhere and sustained epithelial overgrowth was demonstrated for up to 92 days. It was demonstrated that collagen coated PFPE can support epithelial overgrowth in vivo when implanted in the cornea using a superficial keratotomy.",

author = "Hughes, {T. C.} and Chan, {G. Y.N.} and Evans, {M. D.M.} and G. Johnson and Le, {T. P.T.} and G. McFarland and McLean, {K. M.} and X. Nguyen and Sweeney, {D. F.} and Wilkie, {J. S.} and Xie, {R. Z.}",

year = "2004",

language = "English",

isbn = "9781877040191",

pages = "1653",

booktitle = "Transactions - 7th World Biomaterials Congress, 17 -21 May 2004, Sydney, Australia",

note = "World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

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TY - GEN

T1 - Perfluoropolyether corneal onlays

T2 - World Biomaterials Congress

AU - Hughes, T. C.

AU - Chan, G. Y.N.

AU - Evans, M. D.M.

AU - Johnson, G.

AU - Le, T. P.T.

AU - McFarland, G.

AU - McLean, K. M.

AU - Nguyen, X.

AU - Sweeney, D. F.

AU - Wilkie, J. S.

AU - Xie, R. Z.

N1 - Conference code: 7th

PY - 2004

Y1 - 2004

N2 - The development of surgical adhesives, that show potential for adhering synthetic polyfluoropolyether (PEPF) lenticules to a debrided corneal surface, was reported. The PFPE lenticules were prepared by photo-polymerization of the PFPE macromonomers dispersed in a microemulsion. The PFPE lenticules were surface modified by a radio frequency glow discharge (rfgd) plasma polymerization of acetaldehyde, to which collagen was covealently coupled using reductive amination. Lenticules were shown to adhere and sustained epithelial overgrowth was demonstrated for up to 92 days. It was demonstrated that collagen coated PFPE can support epithelial overgrowth in vivo when implanted in the cornea using a superficial keratotomy.

AB - The development of surgical adhesives, that show potential for adhering synthetic polyfluoropolyether (PEPF) lenticules to a debrided corneal surface, was reported. The PFPE lenticules were prepared by photo-polymerization of the PFPE macromonomers dispersed in a microemulsion. The PFPE lenticules were surface modified by a radio frequency glow discharge (rfgd) plasma polymerization of acetaldehyde, to which collagen was covealently coupled using reductive amination. Lenticules were shown to adhere and sustained epithelial overgrowth was demonstrated for up to 92 days. It was demonstrated that collagen coated PFPE can support epithelial overgrowth in vivo when implanted in the cornea using a superficial keratotomy.

UR - http://www.scopus.com/inward/record.url?scp=13844281883&partnerID=8YFLogxK

M3 - Conference Paper

AN - SCOPUS:13844281883

SN - 9781877040191

SP - 1653

BT - Transactions - 7th World Biomaterials Congress, 17 -21 May 2004, Sydney, Australia

Y2 - 17 May 2004 through 21 May 2004

ER -

Perfluoropolyether corneal onlays: Adhesive development

Abstract

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