TY - JOUR
T1 - PGSTE-WATERGATE : an STE-based PGSE NMR sequence with excellent solvent suppression
AU - Zheng, Gang
AU - Stait-Gardner, Timothy
AU - Anil Kumar, P. G.
AU - Torres, Allan M.
AU - Price, William S.
PY - 2008
Y1 - 2008
N2 - A new stimulated-echo based pulsed gradient spin-echo NMR diffusion sequence incorporating WATERGATE solvent suppression, PGSTE-WATERGATE, is presented. The sequence provides superb solvent suppression without any phase distortions. The sequence is simple to set up and particularly suited to measuring diffusion coefficients in aqueous solution such as is commonly required in pharmaceutical and combinatorial applications. The utility of the sequence is demonstrated on samples containing lysozyme and sucrose. Importantly, the high degree of phase-distortion suppression allows more complicated selective π pulses to be used to enhance the selectivity of solvent suppression.
AB - A new stimulated-echo based pulsed gradient spin-echo NMR diffusion sequence incorporating WATERGATE solvent suppression, PGSTE-WATERGATE, is presented. The sequence provides superb solvent suppression without any phase distortions. The sequence is simple to set up and particularly suited to measuring diffusion coefficients in aqueous solution such as is commonly required in pharmaceutical and combinatorial applications. The utility of the sequence is demonstrated on samples containing lysozyme and sucrose. Importantly, the high degree of phase-distortion suppression allows more complicated selective π pulses to be used to enhance the selectivity of solvent suppression.
UR - http://handle.uws.edu.au:8081/1959.7/555774
U2 - 10.1016/j.jmr.2007.12.001
DO - 10.1016/j.jmr.2007.12.001
M3 - Article
C2 - 18086542
SN - 1090-7807
VL - 191
SP - 159
EP - 163
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
IS - 1
ER -