TY - JOUR
T1 - Photoactive and luminescent transition metal complexes as anticancer agents : a guiding light in the search for new and improved cancer treatments
AU - McGhie, Brondwyn S.
AU - Aldrich-Wright, Janice R.
PY - 2022
Y1 - 2022
N2 - Cancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the present study, we focused on innovations in inorganic anticancer therapies, specifically those with photoactive and luminescent properties. Transition metals offer distinct advantages compared to wholly organic compounds in both chemotherapeutics and luminescence properties. Here we report on the characteristics that result from discrete structural changes that have been expertly used to fine-tune their properties, and how diverse inherent luminescent properties have been widely employed to monitor cellular localization to photodynamic therapy.
AB - Cancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the present study, we focused on innovations in inorganic anticancer therapies, specifically those with photoactive and luminescent properties. Transition metals offer distinct advantages compared to wholly organic compounds in both chemotherapeutics and luminescence properties. Here we report on the characteristics that result from discrete structural changes that have been expertly used to fine-tune their properties, and how diverse inherent luminescent properties have been widely employed to monitor cellular localization to photodynamic therapy.
UR - https://hdl.handle.net/1959.7/uws:63365
U2 - 10.3390/biomedicines10030578
DO - 10.3390/biomedicines10030578
M3 - Article
SN - 2227-9059
VL - 10
JO - Biomedicines
JF - Biomedicines
IS - 3
M1 - 578
ER -