Photoactive and luminescent transition metal complexes as anticancer agents : a guiding light in the search for new and improved cancer treatments

Brondwyn S. McGhie, Janice R. Aldrich-Wright

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Cancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the present study, we focused on innovations in inorganic anticancer therapies, specifically those with photoactive and luminescent properties. Transition metals offer distinct advantages compared to wholly organic compounds in both chemotherapeutics and luminescence properties. Here we report on the characteristics that result from discrete structural changes that have been expertly used to fine-tune their properties, and how diverse inherent luminescent properties have been widely employed to monitor cellular localization to photodynamic therapy.
Original languageEnglish
Article number578
Number of pages32
JournalBiomedicines
Volume10
Issue number3
DOIs
Publication statusPublished - 2022

Open Access - Access Right Statement

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

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