Abstract
Intelligent drug delivery membranes were prepared by photocuring poly(acrylic acid) coatings onto poly(2-hydroxyethyl methacrylate) membranes each with model drugs of different molecular weights being incorporated. pH-responsive release behaviours of the model drugs which included sodium salicylate, nicotinamide, nicotinic acid, methylene blue, brilliant green and crystal violet were investigated. Only the membrane with methylene blue incorporated showed a clear pH-responsive release and other drug-incorporated membranes showed no intelligent behaviour. These phenomena were explained in terms of the difference in diffusivity of drugs through polymer matrices of the membranes attributable to the difference in the molecular weights of drugs.
| Original language | English |
|---|---|
| Number of pages | 7 |
| Journal | Radiation physics and chemistry |
| Publication status | Published - 2005 |
Keywords
- biomembranes
- controlled release
- drugs
- matrix diffusion
- molecular weights
- photopolymerization