Abstract
The phosphoinositide-3-kinase like kinases are a family of very large protein kinases. These PIKK proteins have well-established roles in detection and repair of damage to the genome, regulation of the transcriptome and cellular metabolism. Recently there has emerged evidence for links between these proteins and inflammation. While some of these links come from an increased understanding of the impacts of damage to the cell on inflammatory responses, others suggest that PIKK proteins also have direct roles in regulation of immune responses. Particularly evident is the link between DNA damage and innate immune response pathways. Here we review recent findings on the PIKK family of proteins and how they impact on inflammation, particularly activation of the innate immune system.
Original language | English |
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Pages (from-to) | 8-20 |
Number of pages | 13 |
Journal | Immunology and Cell Biology |
Volume | 96 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- inflammation
- natural immunity
- phosphoinositides
- protein kinases