PIKKing a way to regulate inflammation

Hazel Quek, Yi Chieh Lim, Martin F. Lavin, Tara L. Roberts

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The phosphoinositide-3-kinase like kinases are a family of very large protein kinases. These PIKK proteins have well-established roles in detection and repair of damage to the genome, regulation of the transcriptome and cellular metabolism. Recently there has emerged evidence for links between these proteins and inflammation. While some of these links come from an increased understanding of the impacts of damage to the cell on inflammatory responses, others suggest that PIKK proteins also have direct roles in regulation of immune responses. Particularly evident is the link between DNA damage and innate immune response pathways. Here we review recent findings on the PIKK family of proteins and how they impact on inflammation, particularly activation of the innate immune system.
Original languageEnglish
Pages (from-to)8-20
Number of pages13
JournalImmunology and Cell Biology
Volume96
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • inflammation
  • natural immunity
  • phosphoinositides
  • protein kinases

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