TY - JOUR
T1 - Plants and endophytes interaction
T2 - a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites
AU - Kumari, Poonam
AU - Deepa, Nikky
AU - Trivedi, Prabodh Kumar
AU - Singh, Brajesh K.
AU - Srivastava, Vaibhav
AU - Singh, Akanksha
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Many plants possess immense pharmacological properties because of the presence of various therapeutic bioactive secondary metabolites that are of great importance in many pharmaceutical industries. Therefore, to strike a balance between meeting industry demands and conserving natural habitats, medicinal plants are being cultivated on a large scale. However, to enhance the yield and simultaneously manage the various pest infestations, agrochemicals are being routinely used that have a detrimental impact on the whole ecosystem, ranging from biodiversity loss to water pollution, soil degradation, nutrient imbalance and enormous health hazards to both consumers and agricultural workers. To address the challenges, biological eco-friendly alternatives are being looked upon with high hopes where endophytes pitch in as key players due to their tight association with the host plants. The intricate interplay between plants and endophytic microorganisms has emerged as a captivating subject of scientific investigation, with profound implications for the sustainable biosynthesis of pharmaceutically important secondary metabolites. This review delves into the hidden world of the "secret wedlock" between plants and endophytes, elucidating their multifaceted interactions that underpin the synthesis of bioactive compounds with medicinal significance in their plant hosts. Here, we briefly review endophytic diversity association with medicinal plants and highlight the potential role of core endomicrobiome. We also propose that successful implementation of in situ microbiome manipulation through high-end techniques can pave the way towards a more sustainable and pharmaceutically enriched future.There is a correction to the original article which can be found: https://doi.org/10.1186/s12934-023-02234-8
AB - Many plants possess immense pharmacological properties because of the presence of various therapeutic bioactive secondary metabolites that are of great importance in many pharmaceutical industries. Therefore, to strike a balance between meeting industry demands and conserving natural habitats, medicinal plants are being cultivated on a large scale. However, to enhance the yield and simultaneously manage the various pest infestations, agrochemicals are being routinely used that have a detrimental impact on the whole ecosystem, ranging from biodiversity loss to water pollution, soil degradation, nutrient imbalance and enormous health hazards to both consumers and agricultural workers. To address the challenges, biological eco-friendly alternatives are being looked upon with high hopes where endophytes pitch in as key players due to their tight association with the host plants. The intricate interplay between plants and endophytic microorganisms has emerged as a captivating subject of scientific investigation, with profound implications for the sustainable biosynthesis of pharmaceutically important secondary metabolites. This review delves into the hidden world of the "secret wedlock" between plants and endophytes, elucidating their multifaceted interactions that underpin the synthesis of bioactive compounds with medicinal significance in their plant hosts. Here, we briefly review endophytic diversity association with medicinal plants and highlight the potential role of core endomicrobiome. We also propose that successful implementation of in situ microbiome manipulation through high-end techniques can pave the way towards a more sustainable and pharmaceutically enriched future.There is a correction to the original article which can be found: https://doi.org/10.1186/s12934-023-02234-8
KW - Core endomicrobiome
KW - Endophytes
KW - Medicinal plants
KW - Microbiome engineering
KW - Secondary Metabolites
UR - http://www.scopus.com/inward/record.url?scp=85175698259&partnerID=8YFLogxK
U2 - 10.1186/s12934-023-02234-8
DO - 10.1186/s12934-023-02234-8
M3 - Article
C2 - 37925404
AN - SCOPUS:85175698259
SN - 1475-2859
VL - 22
JO - Microbial Cell Factories
JF - Microbial Cell Factories
IS - 1
M1 - 226
ER -