Plasmodium falciparum : new molecular targets with potential for antimalarial drug development

Donald L. Gardiner; Tina S. Skinner-Adams; Christopher L. Brown; Katherine T. Andrews; Colin M. Stack; James S. McCarthy; John P. Dalton; Katharine R. Trenholme

doi:10.1586/ERI.09.93

Plasmodium falciparum : new molecular targets with potential for antimalarial drug development

Donald L. Gardiner, Tina S. Skinner-Adams, Christopher L. Brown, Katherine T. Andrews, Colin M. Stack, James S. McCarthy, John P. Dalton, Katharine R. Trenholme

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Malaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase.

Original language	English
Pages (from-to)	1087-1098
Number of pages	12
Journal	Expert Review of Anti-infective Therapy
Volume	7
Issue number	9
DOIs	https://doi.org/10.1586/ERI.09.93
Publication status	Published - 2009

Keywords

Plasmodium falciparum
antimalarials
pharmacology
drug effects
aspartic proteinases
aminopeptidases
histone deacetylase
malaria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/ERI.09.93

Cite this

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title = "Plasmodium falciparum : new molecular targets with potential for antimalarial drug development",

abstract = "Malaria remains one of the world's most devastating infectious diseases. Drug resistance to all classes of antimalarial agents has now been observed, highlighting the need for new agents that act against novel parasite targets. The complete sequencing of the Plasmodium falciparum genome has allowed the identification of new molecular targets within the parasite that may be amenable to chemotherapeutic intervention. In this review, we investigate four possible targets for the future development of new classes of antimalarial agents. These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase.",

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AU - Gardiner, Donald L.

AU - Skinner-Adams, Tina S.

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AU - Stack, Colin M.

AU - McCarthy, James S.

AU - Dalton, John P.

AU - Trenholme, Katharine R.

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KW - Plasmodium falciparum

KW - antimalarials

KW - pharmacology

KW - drug effects

KW - aspartic proteinases

KW - aminopeptidases

KW - histone deacetylase

KW - malaria

UR - http://handle.uws.edu.au:8081/1959.7/551336

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DO - 10.1586/ERI.09.93

M3 - Article

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ER -

Plasmodium falciparum : new molecular targets with potential for antimalarial drug development

Abstract

Keywords

UN SDGs

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