Platinum-based metal complexes as chloride transporters that trigger apoptosis

Patrick Wang; Mohamed Fares; Radwa A. Eladwy; Deep J. Bhuyan; Xin Wu; William Lewis; Stephen J. Loeb; Lauren K. Macreadie; Philip A. Gale

doi:10.1039/d4sc02115k

Platinum-based metal complexes as chloride transporters that trigger apoptosis

Patrick Wang
, Mohamed Fares
, Radwa A. Eladwy
, Deep J. Bhuyan
, Xin Wu
, William Lewis
, Stephen J. Loeb
, Lauren K. Macreadie
, Philip A. Gale

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.

Original language	English
Pages (from-to)	11584-11593
Number of pages	10
Journal	Chemical Science
Volume	15
Issue number	29
DOIs	https://doi.org/10.1039/d4sc02115k
Publication status	Published - 26 Jun 2024

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© 2024 The Royal Society of Chemistry.

Open Access - Access Right Statement

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/).

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10.1039/d4sc02115k

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abstract = "In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.",

author = "Patrick Wang and Mohamed Fares and Eladwy, \{Radwa A.\} and Bhuyan, \{Deep J.\} and Xin Wu and William Lewis and Loeb, \{Stephen J.\} and Macreadie, \{Lauren K.\} and Gale, \{Philip A.\}",

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TY - JOUR

T1 - Platinum-based metal complexes as chloride transporters that trigger apoptosis

AU - Wang, Patrick

AU - Fares, Mohamed

AU - Eladwy, Radwa A.

AU - Bhuyan, Deep J.

AU - Wu, Xin

AU - Lewis, William

AU - Loeb, Stephen J.

AU - Macreadie, Lauren K.

AU - Gale, Philip A.

PY - 2024/6/26

Y1 - 2024/6/26

N2 - In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.

AB - In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.

UR - https://hdl.handle.net/1959.7/uws:77561

UR - https://www.scopus.com/pages/publications/85197651860

U2 - 10.1039/d4sc02115k

DO - 10.1039/d4sc02115k

M3 - Article

SN - 2041-6520

VL - 15

SP - 11584

EP - 11593

JO - Chemical Science

JF - Chemical Science

IS - 29

ER -

Platinum-based metal complexes as chloride transporters that trigger apoptosis

Abstract

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