Platinum-based metal complexes as chloride transporters that trigger apoptosis

Patrick Wang; Mohamed Fares; Radwa A. Eladwy; Deep J. Bhuyan; Xin Wu; William Lewis; Stephen J. Loeb; Lauren K. Macreadie; Philip A. Gale

doi:10.1039/d4sc02115k

Platinum-based metal complexes as chloride transporters that trigger apoptosis

Patrick Wang, Mohamed Fares, Radwa A. Eladwy, Deep J. Bhuyan, Xin Wu, William Lewis, Stephen J. Loeb, Lauren K. Macreadie, Philip A. Gale

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.

Original language	English
Pages (from-to)	11584-11593
Number of pages	10
Journal	Chemical Science
Volume	15
Issue number	29
DOIs	https://doi.org/10.1039/d4sc02115k
Publication status	Published - 26 Jun 2024

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© 2024 The Royal Society of Chemistry.

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This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/).

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abstract = "In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.",

author = "Patrick Wang and Mohamed Fares and Eladwy, {Radwa A.} and Bhuyan, {Deep J.} and Xin Wu and William Lewis and Loeb, {Stephen J.} and Macreadie, {Lauren K.} and Gale, {Philip A.}",

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doi = "10.1039/d4sc02115k",

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T1 - Platinum-based metal complexes as chloride transporters that trigger apoptosis

AU - Wang, Patrick

AU - Fares, Mohamed

AU - Eladwy, Radwa A.

AU - Bhuyan, Deep J.

AU - Wu, Xin

AU - Lewis, William

AU - Loeb, Stephen J.

AU - Macreadie, Lauren K.

AU - Gale, Philip A.

PY - 2024/6/26

Y1 - 2024/6/26

N2 - In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.

AB - In this paper we demonstrate that Pt(II ) complexes can function as efficient transmembrane chloride transporters. A series of Pt( II) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.

UR - https://hdl.handle.net/1959.7/uws:77561

UR - http://www.scopus.com/inward/record.url?scp=85197651860&partnerID=8YFLogxK

U2 - 10.1039/d4sc02115k

DO - 10.1039/d4sc02115k

M3 - Article

SN - 2041-6520

VL - 15

SP - 11584

EP - 11593

JO - Chemical Science

JF - Chemical Science

IS - 29

ER -

Platinum-based metal complexes as chloride transporters that trigger apoptosis

Abstract

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