TY - JOUR
T1 - Platinum coordination compounds with potent anticancer activity
AU - Deo, Krishant M.
AU - Ang, Dale L.
AU - McGhie, Brondwyn
AU - Rajamanickam, Adeline
AU - Dhiman, Ankita
AU - Khoury, Aleen
AU - Holland, Jason
AU - Bjelosevic, Aleksandra
AU - Pages, Benjamin
AU - Gordon, Christopher
AU - Aldrich-Wright, Janice R.
PY - 2018
Y1 - 2018
N2 - Many international researchers have strived to understand the mechanism of action or improve the efficacy of inorganic coordination compounds that have been identified to exhibit anticancer activity. The inherent challenges of chemotherapy demand that new strategies be developed utilising different mechanisms of action to interrupt the cellular machinery of cancer cells. In Australia, we have benefited from the research of colleagues who have influenced modern platinum chemistry by contributing to our understanding of platinum oxidation and reduction, the mechanism of action of cisplatin, and unique design strategies for new platinum complexes. It was our goal with this review to provide some background in the history and development of platinum(II) and platinum(IV) complexes.
AB - Many international researchers have strived to understand the mechanism of action or improve the efficacy of inorganic coordination compounds that have been identified to exhibit anticancer activity. The inherent challenges of chemotherapy demand that new strategies be developed utilising different mechanisms of action to interrupt the cellular machinery of cancer cells. In Australia, we have benefited from the research of colleagues who have influenced modern platinum chemistry by contributing to our understanding of platinum oxidation and reduction, the mechanism of action of cisplatin, and unique design strategies for new platinum complexes. It was our goal with this review to provide some background in the history and development of platinum(II) and platinum(IV) complexes.
KW - antineoplastic agents
KW - cisplatin
KW - cytotoxicity
KW - platinum compounds
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:44507
U2 - 10.1016/j.ccr.2017.11.014
DO - 10.1016/j.ccr.2017.11.014
M3 - Article
SN - 0010-8545
VL - 375
SP - 148
EP - 163
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
ER -