Polymerase chain reaction tests for the diagnosis of invasive aspergillosis in immunocompromised patients (Protocol)

Mario Cruciani; Carlo Mengoli; Juergen Loeffler; Peter Donnelly; Rosemary Barnes; Brian L. Jones; Lena Klingspor; Oliver Morton; Johan Maertens

doi:10.1002/14651858.CD009551

Polymerase chain reaction tests for the diagnosis of invasive aspergillosis in immunocompromised patients (Protocol)

Mario Cruciani, Carlo Mengoli, Juergen Loeffler, Peter Donnelly, Rosemary Barnes, Brian L. Jones, Lena Klingspor, Oliver Morton, Johan Maertens

School of Science

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

This is the protocol for a review. The objectives are as follows: To provide an overall summary of the diagnostic accuracy of PCR-based tests on blood specimens for the diagnosis of IA in the immunocompromised host. When studies included in the analysis also compare the diagnostic performance of PCR techniques and the GM-ELISA assay, we will comparatively evaluate the diagnostic performance of PCR-based tests and GM-ELISA assays. However, since is not an objective of this review to identify all the studies dealing with GM-ELISA assays and IA, only within-study comparisons will be included in the review. If sufficient data are available, we will explore possible sources of heterogeneity and subgroup differences.

Original language	English
Number of pages	11
Journal	Cochrane Database of Systematic Reviews
Volume	2012
Issue number	1
DOIs	https://doi.org/10.1002/14651858.CD009551
Publication status	Published - 2012

Keywords

GM-ELISA assay
diagnosis
invasive aspergillosis
polymerase chain reaction

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10.1002/14651858.CD009551

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abstract = "This is the protocol for a review. The objectives are as follows: To provide an overall summary of the diagnostic accuracy of PCR-based tests on blood specimens for the diagnosis of IA in the immunocompromised host. When studies included in the analysis also compare the diagnostic performance of PCR techniques and the GM-ELISA assay, we will comparatively evaluate the diagnostic performance of PCR-based tests and GM-ELISA assays. However, since is not an objective of this review to identify all the studies dealing with GM-ELISA assays and IA, only within-study comparisons will be included in the review. If sufficient data are available, we will explore possible sources of heterogeneity and subgroup differences.",

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AU - Cruciani, Mario

AU - Mengoli, Carlo

AU - Loeffler, Juergen

AU - Donnelly, Peter

AU - Barnes, Rosemary

AU - Jones, Brian L.

AU - Klingspor, Lena

AU - Morton, Oliver

AU - Maertens, Johan

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N2 - This is the protocol for a review. The objectives are as follows: To provide an overall summary of the diagnostic accuracy of PCR-based tests on blood specimens for the diagnosis of IA in the immunocompromised host. When studies included in the analysis also compare the diagnostic performance of PCR techniques and the GM-ELISA assay, we will comparatively evaluate the diagnostic performance of PCR-based tests and GM-ELISA assays. However, since is not an objective of this review to identify all the studies dealing with GM-ELISA assays and IA, only within-study comparisons will be included in the review. If sufficient data are available, we will explore possible sources of heterogeneity and subgroup differences.

AB - This is the protocol for a review. The objectives are as follows: To provide an overall summary of the diagnostic accuracy of PCR-based tests on blood specimens for the diagnosis of IA in the immunocompromised host. When studies included in the analysis also compare the diagnostic performance of PCR techniques and the GM-ELISA assay, we will comparatively evaluate the diagnostic performance of PCR-based tests and GM-ELISA assays. However, since is not an objective of this review to identify all the studies dealing with GM-ELISA assays and IA, only within-study comparisons will be included in the review. If sufficient data are available, we will explore possible sources of heterogeneity and subgroup differences.

KW - GM-ELISA assay

KW - diagnosis

KW - invasive aspergillosis

KW - polymerase chain reaction

UR - http://handle.uws.edu.au:8081/1959.7/516963

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M3 - Article

SN - 1361-6137

VL - 2012

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

IS - 1

ER -

Polymerase chain reaction tests for the diagnosis of invasive aspergillosis in immunocompromised patients (Protocol)

Abstract

Keywords

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