Predictive and prognostic value of circulating tumor cell detection in lung cancer : a clinician's perspective

Annette Tognela; Kevin J. Spring; Therese Becker; Nicole J. Caixeiro; Victoria J. Bray; Po Yee Yip; Wei Chua; Stephanie H. Lim; Paul de Souza

doi:10.1016/j.critrevonc.2014.10.001

Predictive and prognostic value of circulating tumor cell detection in lung cancer : a clinician's perspective

Annette Tognela, Kevin J. Spring, Therese Becker, Nicole J. Caixeiro, Victoria J. Bray, Po Yee Yip, Wei Chua, Stephanie H. Lim, Paul de Souza

School of Medicine

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

There is increasing evidence for the use of circulating tumor cells (CTCs) as a "liquid biopsy" for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice.

Original language	English
Pages (from-to)	90-102
Number of pages	13
Journal	Critical Reviews in Oncology/Hematology
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/j.critrevonc.2014.10.001
Publication status	Published - 2015

Keywords

biomarkers
circulating tumour cells
lung cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.critrevonc.2014.10.001

http://ezproxy.uws.edu.au/login?url=http://doi.org/10.1016/j.critrevonc.2014.10.001

Cite this

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title = "Predictive and prognostic value of circulating tumor cell detection in lung cancer : a clinician's perspective",

abstract = "There is increasing evidence for the use of circulating tumor cells (CTCs) as a {"}liquid biopsy{"} for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice.",

keywords = "biomarkers, circulating tumour cells, lung cancer",

author = "Annette Tognela and Spring, {Kevin J.} and Therese Becker and Caixeiro, {Nicole J.} and Bray, {Victoria J.} and Yip, {Po Yee} and Wei Chua and Lim, {Stephanie H.} and Souza, {Paul de}",

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T1 - Predictive and prognostic value of circulating tumor cell detection in lung cancer : a clinician's perspective

AU - Tognela, Annette

AU - Spring, Kevin J.

AU - Becker, Therese

AU - Caixeiro, Nicole J.

AU - Bray, Victoria J.

AU - Yip, Po Yee

AU - Chua, Wei

AU - Lim, Stephanie H.

AU - Souza, Paul de

PY - 2015

Y1 - 2015

N2 - There is increasing evidence for the use of circulating tumor cells (CTCs) as a "liquid biopsy" for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice.

AB - There is increasing evidence for the use of circulating tumor cells (CTCs) as a "liquid biopsy" for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice.

KW - biomarkers

KW - circulating tumour cells

KW - lung cancer

UR - http://hdl.handle.net/1959.7/uws:30602

U2 - 10.1016/j.critrevonc.2014.10.001

DO - 10.1016/j.critrevonc.2014.10.001

M3 - Article

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SN - 1040-8428

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SP - 90

EP - 102

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

IS - 2

ER -

Predictive and prognostic value of circulating tumor cell detection in lung cancer : a clinician's perspective

Abstract

Keywords

UN SDGs

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