Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle

Chun Guang Li; Michael John Rand

doi:10.1016/0014-2999(89)90640-7

Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle

Chun Guang Li
, Michael John Rand

University of Melbourne

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of α₁- (methoxamine) or α₂-adrenoceptors (clonidine, rilmenidine) increased tone and reduced NANC relaxations. Carbachol also increasedtoned but produced a greater reduction of NANC relaxations. The findings suggest that activation of prejunctional muscarinic receptors on NANC terminals inhibits transmitter release, but there is no evidence for prejunctional α-adrenoceptors.

Original language	English
Pages (from-to)	107-110
Number of pages	4
Journal	European Journal of Pharmacology
Volume	168
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(89)90640-7
Publication status	Published - 1 Sept 1989
Externally published	Yes

Keywords

(Prejunctional receptors)
Anococcygeus (rat)
Clonidine
McN-A-343
Methoxamine
Non-adrenergic non-cholinergic (NANC) transmission
Rilmenidine

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10.1016/0014-2999(89)90640-7

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title = "Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle",

abstract = "The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of α1- (methoxamine) or α2-adrenoceptors (clonidine, rilmenidine) increased tone and reduced NANC relaxations. Carbachol also increasedtoned but produced a greater reduction of NANC relaxations. The findings suggest that activation of prejunctional muscarinic receptors on NANC terminals inhibits transmitter release, but there is no evidence for prejunctional α-adrenoceptors.",

keywords = "(Prejunctional receptors), Anococcygeus (rat), Clonidine, McN-A-343, Methoxamine, Non-adrenergic non-cholinergic (NANC) transmission, Rilmenidine",

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doi = "10.1016/0014-2999(89)90640-7",

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T1 - Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle

AU - Li, Chun Guang

AU - Rand, Michael John

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N2 - The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of α1- (methoxamine) or α2-adrenoceptors (clonidine, rilmenidine) increased tone and reduced NANC relaxations. Carbachol also increasedtoned but produced a greater reduction of NANC relaxations. The findings suggest that activation of prejunctional muscarinic receptors on NANC terminals inhibits transmitter release, but there is no evidence for prejunctional α-adrenoceptors.

AB - The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of α1- (methoxamine) or α2-adrenoceptors (clonidine, rilmenidine) increased tone and reduced NANC relaxations. Carbachol also increasedtoned but produced a greater reduction of NANC relaxations. The findings suggest that activation of prejunctional muscarinic receptors on NANC terminals inhibits transmitter release, but there is no evidence for prejunctional α-adrenoceptors.

KW - (Prejunctional receptors)

KW - Anococcygeus (rat)

KW - Clonidine

KW - McN-A-343

KW - Methoxamine

KW - Non-adrenergic non-cholinergic (NANC) transmission

KW - Rilmenidine

UR - https://www.scopus.com/pages/publications/0024419210

U2 - 10.1016/0014-2999(89)90640-7

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle

Abstract

Keywords

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