TY - JOUR
T1 - Preparation and biological assessment of 177Lu-BPAMD as a high potential agent for bone pain palliation therapy: comparison with 177Lu-EDTMP
AU - Yousefnia, Hassan
AU - Zolghadri, Samaneh
AU - Sadeghi, Hamid Reza
AU - Naderi, Mojdeh
AU - Jalilian, Amir Reza
AU - Shanehsazzadeh, Saeed
PY - 2016/2
Y1 - 2016/2
N2 - In this study, Lu-177-(4-{[(bis(phosphonomethyl))-carbamoyl] methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl) acetic acid (Lu-177-BPAMD) was successfully prepared. The quality control, partition coefficient, hydroxyapatite binding assay and stability of the complex were determined. For better comparison, biodistribution patterns of Lu-177-BPAMD and Lu-177-EDTMP complexes were compared in same animal model. Lu-177-BPAMD was prepared with high radiochemical purity (>93 %) and specific activity of 534 GBq/mmol at the optimal conditions. Comparative study between Lu-177-BPAMD and Lu-177-EDTMP indicated higher bone uptake and lesser accumulation in the other organs for Lu-177-BPAMD. Lu-177-BPAMD can be considered as a promising agent for bone pain palliation in the near future.
AB - In this study, Lu-177-(4-{[(bis(phosphonomethyl))-carbamoyl] methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl) acetic acid (Lu-177-BPAMD) was successfully prepared. The quality control, partition coefficient, hydroxyapatite binding assay and stability of the complex were determined. For better comparison, biodistribution patterns of Lu-177-BPAMD and Lu-177-EDTMP complexes were compared in same animal model. Lu-177-BPAMD was prepared with high radiochemical purity (>93 %) and specific activity of 534 GBq/mmol at the optimal conditions. Comparative study between Lu-177-BPAMD and Lu-177-EDTMP indicated higher bone uptake and lesser accumulation in the other organs for Lu-177-BPAMD. Lu-177-BPAMD can be considered as a promising agent for bone pain palliation in the near future.
UR - https://go.openathens.net/redirector/westernsydney.edu.au?url=https://doi.org/10.1007/s10967-015-4225-z
U2 - 10.1007/s10967-015-4225-z
DO - 10.1007/s10967-015-4225-z
M3 - Article
SN - 0236-5731
VL - 307
SP - 1243
EP - 1251
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
IS - 2
ER -
