Preparation and biological assessment of 177Lu-BPAMD as a high potential agent for bone pain palliation therapy: comparison with 177Lu-EDTMP

Hassan Yousefnia; Samaneh Zolghadri; Hamid Reza Sadeghi; Mojdeh Naderi; Amir Reza Jalilian; Saeed Shanehsazzadeh

doi:10.1007/s10967-015-4225-z

Preparation and biological assessment of 177Lu-BPAMD as a high potential agent for bone pain palliation therapy: comparison with 177Lu-EDTMP

Hassan Yousefnia
, Samaneh Zolghadri
, Hamid Reza Sadeghi
, Mojdeh Naderi
, Amir Reza Jalilian
, Saeed Shanehsazzadeh

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

In this study, Lu-177-(4-{[(bis(phosphonomethyl))-carbamoyl] methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl) acetic acid (Lu-177-BPAMD) was successfully prepared. The quality control, partition coefficient, hydroxyapatite binding assay and stability of the complex were determined. For better comparison, biodistribution patterns of Lu-177-BPAMD and Lu-177-EDTMP complexes were compared in same animal model. Lu-177-BPAMD was prepared with high radiochemical purity (>93 %) and specific activity of 534 GBq/mmol at the optimal conditions. Comparative study between Lu-177-BPAMD and Lu-177-EDTMP indicated higher bone uptake and lesser accumulation in the other organs for Lu-177-BPAMD. Lu-177-BPAMD can be considered as a promising agent for bone pain palliation in the near future.

Original language	English
Pages (from-to)	1243-1251
Number of pages	9
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	307
Issue number	2
DOIs	https://doi.org/10.1007/s10967-015-4225-z
Publication status	Published - Feb 2016
Externally published	Yes

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@article{cecabda0728040648d351f5251f350fc,

title = "Preparation and biological assessment of 177Lu-BPAMD as a high potential agent for bone pain palliation therapy: comparison with 177Lu-EDTMP",

abstract = "In this study, Lu-177-(4-\{[(bis(phosphonomethyl))-carbamoyl] methyl\}-7,10-bis(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl) acetic acid (Lu-177-BPAMD) was successfully prepared. The quality control, partition coefficient, hydroxyapatite binding assay and stability of the complex were determined. For better comparison, biodistribution patterns of Lu-177-BPAMD and Lu-177-EDTMP complexes were compared in same animal model. Lu-177-BPAMD was prepared with high radiochemical purity (>93 \%) and specific activity of 534 GBq/mmol at the optimal conditions. Comparative study between Lu-177-BPAMD and Lu-177-EDTMP indicated higher bone uptake and lesser accumulation in the other organs for Lu-177-BPAMD. Lu-177-BPAMD can be considered as a promising agent for bone pain palliation in the near future.",

author = "Hassan Yousefnia and Samaneh Zolghadri and Sadeghi, \{Hamid Reza\} and Mojdeh Naderi and Jalilian, \{Amir Reza\} and Saeed Shanehsazzadeh",

year = "2016",

month = feb,

doi = "10.1007/s10967-015-4225-z",

language = "English",

volume = "307",

pages = "1243--1251",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Springer Nature",

number = "2",

}

Preparation and biological assessment of 177Lu-BPAMD as a high potential agent for bone pain palliation therapy: comparison with 177Lu-EDTMP. / Yousefnia, Hassan; Zolghadri, Samaneh; Sadeghi, Hamid Reza et al.
In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 307, No. 2, 02.2016, p. 1243-1251.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Preparation and biological assessment of 177Lu-BPAMD as a high potential agent for bone pain palliation therapy: comparison with 177Lu-EDTMP

AU - Yousefnia, Hassan

AU - Zolghadri, Samaneh

AU - Sadeghi, Hamid Reza

AU - Naderi, Mojdeh

AU - Jalilian, Amir Reza

AU - Shanehsazzadeh, Saeed

PY - 2016/2

Y1 - 2016/2

N2 - In this study, Lu-177-(4-{[(bis(phosphonomethyl))-carbamoyl] methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl) acetic acid (Lu-177-BPAMD) was successfully prepared. The quality control, partition coefficient, hydroxyapatite binding assay and stability of the complex were determined. For better comparison, biodistribution patterns of Lu-177-BPAMD and Lu-177-EDTMP complexes were compared in same animal model. Lu-177-BPAMD was prepared with high radiochemical purity (>93 %) and specific activity of 534 GBq/mmol at the optimal conditions. Comparative study between Lu-177-BPAMD and Lu-177-EDTMP indicated higher bone uptake and lesser accumulation in the other organs for Lu-177-BPAMD. Lu-177-BPAMD can be considered as a promising agent for bone pain palliation in the near future.

AB - In this study, Lu-177-(4-{[(bis(phosphonomethyl))-carbamoyl] methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl) acetic acid (Lu-177-BPAMD) was successfully prepared. The quality control, partition coefficient, hydroxyapatite binding assay and stability of the complex were determined. For better comparison, biodistribution patterns of Lu-177-BPAMD and Lu-177-EDTMP complexes were compared in same animal model. Lu-177-BPAMD was prepared with high radiochemical purity (>93 %) and specific activity of 534 GBq/mmol at the optimal conditions. Comparative study between Lu-177-BPAMD and Lu-177-EDTMP indicated higher bone uptake and lesser accumulation in the other organs for Lu-177-BPAMD. Lu-177-BPAMD can be considered as a promising agent for bone pain palliation in the near future.

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U2 - 10.1007/s10967-015-4225-z

DO - 10.1007/s10967-015-4225-z

M3 - Article

SN - 0236-5731

VL - 307

SP - 1243

EP - 1251

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

Preparation and biological assessment of 177Lu-BPAMD as a high potential agent for bone pain palliation therapy: comparison with 177Lu-EDTMP

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