Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa : a systematic review and meta-analysis of observational studies

Animut Alebel; Amsalu Taye Wondemagegn; Cheru Tesema; Getiye Dejenu Kibret; Fasil Wagnew; Pammla Petrucka; Amit Arora; Amare Demsie Ayele; Mulunesh Alemayehu; Setegn Eshetie

doi:10.1186/s12879-019-3892-8

Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa : a systematic review and meta-analysis of observational studies

Animut Alebel, Amsalu Taye Wondemagegn, Cheru Tesema, Getiye Dejenu Kibret, Fasil Wagnew, Pammla Petrucka, Amit Arora, Amare Demsie Ayele, Mulunesh Alemayehu, Setegn Eshetie

Western Sydney University

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Abstract

Background: Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa. Methods: Four international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I 2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors. Results: In the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients. Conclusion: Diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients.

Original language	English
Article number	254
Number of pages	11
Journal	BMC Infectious Diseases
Volume	19
DOIs	https://doi.org/10.1186/s12879-019-3892-8
Publication status	Published - 2019

Open Access - Access Right Statement

© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Keywords

Africa, Sub-Saharan
diabetes
tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12879-019-3892-8

Cite this

Alebel, A., Wondemagegn, A. T., Tesema, C., Kibret, G. D., Wagnew, F., Petrucka, P., Arora, A., Ayele, A. D., Alemayehu, M., & Eshetie, S. (2019). Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa : a systematic review and meta-analysis of observational studies. BMC Infectious Diseases, 19, Article 254. https://doi.org/10.1186/s12879-019-3892-8

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title = "Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa : a systematic review and meta-analysis of observational studies",

abstract = "Background: Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa. Methods: Four international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I 2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors. Results: In the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients. Conclusion: Diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients.",

keywords = "Africa, Sub-Saharan, diabetes, tuberculosis",

author = "Animut Alebel and Wondemagegn, {Amsalu Taye} and Cheru Tesema and Kibret, {Getiye Dejenu} and Fasil Wagnew and Pammla Petrucka and Amit Arora and Ayele, {Amare Demsie} and Mulunesh Alemayehu and Setegn Eshetie",

year = "2019",

doi = "10.1186/s12879-019-3892-8",

language = "English",

volume = "19",

journal = "BMC Infectious Diseases",

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T1 - Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa : a systematic review and meta-analysis of observational studies

AU - Alebel, Animut

AU - Wondemagegn, Amsalu Taye

AU - Tesema, Cheru

AU - Kibret, Getiye Dejenu

AU - Wagnew, Fasil

AU - Petrucka, Pammla

AU - Arora, Amit

AU - Ayele, Amare Demsie

AU - Alemayehu, Mulunesh

AU - Eshetie, Setegn

PY - 2019

Y1 - 2019

N2 - Background: Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa. Methods: Four international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I 2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors. Results: In the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients. Conclusion: Diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients.

AB - Background: Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa. Methods: Four international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I 2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors. Results: In the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients. Conclusion: Diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients.

KW - Africa, Sub-Saharan

KW - diabetes

KW - tuberculosis

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:51694

U2 - 10.1186/s12879-019-3892-8

DO - 10.1186/s12879-019-3892-8

M3 - Article

SN - 1471-2334

VL - 19

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

M1 - 254

ER -

Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa : a systematic review and meta-analysis of observational studies

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

Access to Document

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