Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy

Chenxiang Wang; Yibin Sun; Wenjing Liu; Yang Liu; Sualiha Afzal; Jahnavi Grover; Dennis Chang; Gerald Münch; Chun Guang Li; Shiling Lin; Jianyu Chen; Yiping Zhang; Zaixing Cheng; Yanxiang Lin; Yanfang Zheng; Mingqing Huang; Xian Zhou

doi:10.3389/fendo.2022.953305

Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy

Chenxiang Wang, Yibin Sun, Wenjing Liu, Yang Liu, Sualiha Afzal, Jahnavi Grover, Dennis Chang, Gerald Münch, Chun Guang Li, Shiling Lin, Jianyu Chen, Yiping Zhang, Zaixing Cheng, Yanxiang Lin, Yanfang Zheng, Mingqing Huang, Xian Zhou

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Abstract

Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular function. The cellular protective effects of Cur, Bai and Cur+Bai (1:1, w/w) were tested in H2O2 (2.5 mM) impaired EA. hy926 cells. Wistar rats were treated with vehicle control as the control group, Goto-Kakizaki rats (n=5 each group) were treated with vehicle control (model group), Cur (150 mg/kg), Bai (150 mg/kg), or Cur+Bai (75 mg/kg Cur + 75 mg/kg Bai, OG) for 4 weeks after a four-week high-fat diet to investigate the changes on blood vessel against diabetic angiopathy. Our results showed that Cur+Bai synergistically restored the endothelial cell survival and exhibited greater effects on lowering the fasting blood glucose and blood lipids in rats comparing to individual compounds. Cur+Bai repaired the blood vessel structure in the aortic arch and mid thoracic aorta. The network pharmacology analysis showed that Nrf2 and MAPK/JNK kinase were highly relevant to the multi-targeted action of Cur+Bai which has been confirmed in the in vitro and in vivo studies. In conclusion, Cur+Bai demonstrated an enhanced activity in attenuating endothelial dysfunction against oxidative damage and effectively protected vascular function in diabetic angiopathy rats.

Original language	English
Article number	953305
Number of pages	17
Journal	Frontiers in Endocrinology
Volume	13
DOIs	https://doi.org/10.3389/fendo.2022.953305
Publication status	Published - 18 Aug 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Wang, Sun, Liu, Liu, Afzal, Grover, Chang, Münch, Li, Lin, Chen, Zhang, Cheng, Lin, Zheng, Huang and Zhou.

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© 2022 Wang, Sun, Liu, Liu, Afzal, Grover, Chang, Münch, Li, Lin, Chen, Zhang, Cheng, Lin, Zheng, Huang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Wang, C., Sun, Y., Liu, W., Liu, Y., Afzal, S., Grover, J., Chang, D., Münch, G., Li, C. G., Lin, S., Chen, J., Zhang, Y., Cheng, Z., Lin, Y., Zheng, Y., Huang, M., & Zhou, X. (2022). Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy. Frontiers in Endocrinology, 13, Article 953305. https://doi.org/10.3389/fendo.2022.953305

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title = "Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy",

abstract = "Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular function. The cellular protective effects of Cur, Bai and Cur+Bai (1:1, w/w) were tested in H2O2 (2.5 mM) impaired EA. hy926 cells. Wistar rats were treated with vehicle control as the control group, Goto-Kakizaki rats (n=5 each group) were treated with vehicle control (model group), Cur (150 mg/kg), Bai (150 mg/kg), or Cur+Bai (75 mg/kg Cur + 75 mg/kg Bai, OG) for 4 weeks after a four-week high-fat diet to investigate the changes on blood vessel against diabetic angiopathy. Our results showed that Cur+Bai synergistically restored the endothelial cell survival and exhibited greater effects on lowering the fasting blood glucose and blood lipids in rats comparing to individual compounds. Cur+Bai repaired the blood vessel structure in the aortic arch and mid thoracic aorta. The network pharmacology analysis showed that Nrf2 and MAPK/JNK kinase were highly relevant to the multi-targeted action of Cur+Bai which has been confirmed in the in vitro and in vivo studies. In conclusion, Cur+Bai demonstrated an enhanced activity in attenuating endothelial dysfunction against oxidative damage and effectively protected vascular function in diabetic angiopathy rats.",

author = "Chenxiang Wang and Yibin Sun and Wenjing Liu and Yang Liu and Sualiha Afzal and Jahnavi Grover and Dennis Chang and Gerald M{\"u}nch and Li, {Chun Guang} and Shiling Lin and Jianyu Chen and Yiping Zhang and Zaixing Cheng and Yanxiang Lin and Yanfang Zheng and Mingqing Huang and Xian Zhou",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Wang, Sun, Liu, Liu, Afzal, Grover, Chang, M{\"u}nch, Li, Lin, Chen, Zhang, Cheng, Lin, Zheng, Huang and Zhou.",

year = "2022",

month = aug,

day = "18",

doi = "10.3389/fendo.2022.953305",

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T1 - Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy

AU - Wang, Chenxiang

AU - Sun, Yibin

AU - Liu, Wenjing

AU - Liu, Yang

AU - Afzal, Sualiha

AU - Grover, Jahnavi

AU - Chang, Dennis

AU - Münch, Gerald

AU - Li, Chun Guang

AU - Lin, Shiling

AU - Chen, Jianyu

AU - Zhang, Yiping

AU - Cheng, Zaixing

AU - Lin, Yanxiang

AU - Zheng, Yanfang

AU - Huang, Mingqing

AU - Zhou, Xian

PY - 2022/8/18

Y1 - 2022/8/18

N2 - Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular function. The cellular protective effects of Cur, Bai and Cur+Bai (1:1, w/w) were tested in H2O2 (2.5 mM) impaired EA. hy926 cells. Wistar rats were treated with vehicle control as the control group, Goto-Kakizaki rats (n=5 each group) were treated with vehicle control (model group), Cur (150 mg/kg), Bai (150 mg/kg), or Cur+Bai (75 mg/kg Cur + 75 mg/kg Bai, OG) for 4 weeks after a four-week high-fat diet to investigate the changes on blood vessel against diabetic angiopathy. Our results showed that Cur+Bai synergistically restored the endothelial cell survival and exhibited greater effects on lowering the fasting blood glucose and blood lipids in rats comparing to individual compounds. Cur+Bai repaired the blood vessel structure in the aortic arch and mid thoracic aorta. The network pharmacology analysis showed that Nrf2 and MAPK/JNK kinase were highly relevant to the multi-targeted action of Cur+Bai which has been confirmed in the in vitro and in vivo studies. In conclusion, Cur+Bai demonstrated an enhanced activity in attenuating endothelial dysfunction against oxidative damage and effectively protected vascular function in diabetic angiopathy rats.

AB - Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular function. The cellular protective effects of Cur, Bai and Cur+Bai (1:1, w/w) were tested in H2O2 (2.5 mM) impaired EA. hy926 cells. Wistar rats were treated with vehicle control as the control group, Goto-Kakizaki rats (n=5 each group) were treated with vehicle control (model group), Cur (150 mg/kg), Bai (150 mg/kg), or Cur+Bai (75 mg/kg Cur + 75 mg/kg Bai, OG) for 4 weeks after a four-week high-fat diet to investigate the changes on blood vessel against diabetic angiopathy. Our results showed that Cur+Bai synergistically restored the endothelial cell survival and exhibited greater effects on lowering the fasting blood glucose and blood lipids in rats comparing to individual compounds. Cur+Bai repaired the blood vessel structure in the aortic arch and mid thoracic aorta. The network pharmacology analysis showed that Nrf2 and MAPK/JNK kinase were highly relevant to the multi-targeted action of Cur+Bai which has been confirmed in the in vitro and in vivo studies. In conclusion, Cur+Bai demonstrated an enhanced activity in attenuating endothelial dysfunction against oxidative damage and effectively protected vascular function in diabetic angiopathy rats.

UR - https://hdl.handle.net/1959.7/uws:69883

U2 - 10.3389/fendo.2022.953305

DO - 10.3389/fendo.2022.953305

M3 - Article

SN - 1664-2392

VL - 13

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 953305

ER -

Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy

Abstract

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UN SDGs

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