PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer

Brian Wan-Chi Tse; Gary J. Cowin; Carolina Soekmadji; Lidija Jovanovic; Raja S. Vasireddy; Ming-Tat Ling; Aparajita Khatri; Tianqing Liu; Benjamin Thierry; Pamela J. Russell

doi:10.2217/NNM.14.122

PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer

Brian Wan-Chi Tse, Gary J. Cowin, Carolina Soekmadji, Lidija Jovanovic, Raja S. Vasireddy, Ming-Tat Ling, Aparajita Khatri, Tianqing Liu, Benjamin Thierry, Pamela J. Russell

Western Sydney University

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Aim: To evaluate the potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of PSMA, to enhance MRI of prostate cancer. Materials & methods: Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2 h and 24 h after intravenous injection of J591-MNPs, or non-targeting MNPs. Results & conclusion: In vitro, MNPs did not affect prostate cancer cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. Magnetic resonance contrast of tumors was increased in vivo using PSMA-targeting MNPs, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance magnetic resonance detection/localization of prostate cancer.

Original language	English
Pages (from-to)	375-386
Number of pages	12
Journal	Nanomedicine
Volume	10
Issue number	3
DOIs	https://doi.org/10.2217/NNM.14.122
Publication status	Published - 2015

Keywords

cancer
iron oxides
magnetic resonance imaging
nanoparticles
prostate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/NNM.14.122

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title = "PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer",

abstract = "Aim: To evaluate the potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of PSMA, to enhance MRI of prostate cancer. Materials & methods: Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2 h and 24 h after intravenous injection of J591-MNPs, or non-targeting MNPs. Results & conclusion: In vitro, MNPs did not affect prostate cancer cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. Magnetic resonance contrast of tumors was increased in vivo using PSMA-targeting MNPs, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance magnetic resonance detection/localization of prostate cancer.",

keywords = "cancer, iron oxides, magnetic resonance imaging, nanoparticles, prostate",

author = "Tse, {Brian Wan-Chi} and Cowin, {Gary J.} and Carolina Soekmadji and Lidija Jovanovic and Vasireddy, {Raja S.} and Ming-Tat Ling and Aparajita Khatri and Tianqing Liu and Benjamin Thierry and Russell, {Pamela J.}",

year = "2015",

doi = "10.2217/NNM.14.122",

language = "English",

volume = "10",

pages = "375--386",

journal = "Nanomedicine",

issn = "1748-6963",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer

AU - Tse, Brian Wan-Chi

AU - Cowin, Gary J.

AU - Soekmadji, Carolina

AU - Jovanovic, Lidija

AU - Vasireddy, Raja S.

AU - Ling, Ming-Tat

AU - Khatri, Aparajita

AU - Liu, Tianqing

AU - Thierry, Benjamin

AU - Russell, Pamela J.

PY - 2015

Y1 - 2015

N2 - Aim: To evaluate the potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of PSMA, to enhance MRI of prostate cancer. Materials & methods: Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2 h and 24 h after intravenous injection of J591-MNPs, or non-targeting MNPs. Results & conclusion: In vitro, MNPs did not affect prostate cancer cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. Magnetic resonance contrast of tumors was increased in vivo using PSMA-targeting MNPs, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance magnetic resonance detection/localization of prostate cancer.

AB - Aim: To evaluate the potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of PSMA, to enhance MRI of prostate cancer. Materials & methods: Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2 h and 24 h after intravenous injection of J591-MNPs, or non-targeting MNPs. Results & conclusion: In vitro, MNPs did not affect prostate cancer cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. Magnetic resonance contrast of tumors was increased in vivo using PSMA-targeting MNPs, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance magnetic resonance detection/localization of prostate cancer.

KW - cancer

KW - iron oxides

KW - magnetic resonance imaging

KW - nanoparticles

KW - prostate

UR - https://hdl.handle.net/1959.7/uws:56751

U2 - 10.2217/NNM.14.122

DO - 10.2217/NNM.14.122

M3 - Article

SN - 1748-6963

SN - 1743-5889

VL - 10

SP - 375

EP - 386

JO - Nanomedicine

JF - Nanomedicine

IS - 3

ER -

PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer

Abstract

Keywords

UN SDGs

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