Psychiatric and medical comorbidities of eating disorders : findings from a rapid review of the literature

Ashlea Hambleton; Genevieve Pepin; Anvi Le; Danielle Maloney; Stephen Touyz; Sarah Maguire; National Eating Disorder Research Consortium; Janet Conti; Phillipa Hay; Phillip Aouad; Sarah Barakat; Robert Boakes; Leah Brennan; Emma Bryant; Susan Byrne; Belinda Caldwell; Shannon Calvert; Bronny Carroll; David Castle; Ian Caterson; Belinda Chelius; Lyn Chiem; Simon Clarke; Lexi Crouch; Genevieve Dammery; Natasha Dzajkovski; Jasmine Fardouly; Carmen Felicia; John Feneley; Amber-Marie Firriolo; Nasim Foroughi; Mathew Fuller-Tyszkiewicz; Anthea Fursland; Veronica Gonzalez-Arce; Bethanie Gouldthorp; Kelly Grifn; Scott Grifths; Amy Hannigan; Mel Hart; Susan Hart; Ian Hickie; Francis Kay-Lambkin; Ross King; Michael Kohn; Eyza Koreshe; Isabel Krug; Jake Linardon; Randall Long; Amanda Long; Sloane Madden; al et al

doi:10.1186/s40337-022-00654-2

Psychiatric and medical comorbidities of eating disorders : findings from a rapid review of the literature

Ashlea Hambleton
, Genevieve Pepin
, Anvi Le
, Danielle Maloney
, Stephen Touyz
, Sarah Maguire
, National Eating Disorder Research Consortium
, Janet Conti
, Phillipa Hay
, Phillip Aouad
, Sarah Barakat
, Robert Boakes
, Leah Brennan
, Emma Bryant
, Susan Byrne
, Belinda Caldwell
, Shannon Calvert
, Bronny Carroll
, David Castle
, Ian Caterson

Belinda Chelius, Lyn Chiem, Simon Clarke, Lexi Crouch, Genevieve Dammery, Natasha Dzajkovski, Jasmine Fardouly, Carmen Felicia, John Feneley, Amber-Marie Firriolo, Nasim Foroughi, Mathew Fuller-Tyszkiewicz, Anthea Fursland, Veronica Gonzalez-Arce, Bethanie Gouldthorp, Kelly Grifn, Scott Grifths, Amy Hannigan, Mel Hart, Susan Hart, Ian Hickie, Francis Kay-Lambkin, Ross King, Michael Kohn, Eyza Koreshe, Isabel Krug, Jake Linardon, Randall Long, Amanda Long, Sloane Madden, al et al

Research output: Contribution to journal › Article › peer-review

253 Citations (Scopus)

Abstract

Background: Eating disorders (EDs) are potentially severe, complex, and life-threatening illnesses. The mortality rate of EDs is significantly elevated compared to other psychiatric conditions, primarily due to medical complications and suicide. The current rapid review aimed to summarise the literature and identify gaps in knowledge relating to any psychiatric and medical comorbidities of eating disorders. Methods: This paper forms part of a rapid review) series scoping the evidence base for the field of EDs, conducted to inform the Australian National Eating Disorders Research and Translation Strategy 2021–2031, funded and released by the Australian Government. ScienceDirect, PubMed and Ovid/Medline were searched for English-language studies focused on the psychiatric and medical comorbidities of EDs, published between 2009 and 2021. High-level evidence such as meta-analyses, large population studies and Randomised Control Trials were prioritised. Results: A total of 202 studies were included in this review, with 58% pertaining to psychiatric comorbidities and 42% to medical comorbidities. For EDs in general, the most prevalent psychiatric comorbidities were anxiety (up to 62%), mood (up to 54%) and substance use and post-traumatic stress disorders (similar comorbidity rates up to 27%). The review also noted associations between specific EDs and non-suicidal self-injury, personality disorders, and neurodevelopmental disorders. EDs were complicated by medical comorbidities across the neuroendocrine, skeletal, nutritional, gastrointestinal, dental, and reproductive systems. Medical comorbidities can precede, occur alongside or emerge as a complication of the ED. Conclusions: This review provides a thorough overview of the comorbid psychiatric and medical conditions co-occurring with EDs. High psychiatric and medical comorbidity rates were observed in people with EDs, with comorbidities contributing to increased ED symptom severity, maintenance of some ED behaviours, and poorer functioning as well as treatment outcomes. Early identification and management of psychiatric and medical comorbidities in people with an ED may improve response to treatment and overall outcomes.

Original language	English
Article number	132
Number of pages	23
Journal	Journal of Eating Disorders
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s40337-022-00654-2
Publication status	Published - Dec 2022

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© 2022, The Author(s).

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Hambleton, A., Pepin, G., Le, A., Maloney, D., Touyz, S., Maguire, S., National Eating Disorder Research Consortium, Conti, J., Hay, P., Aouad, P., Barakat, S., Boakes, R., Brennan, L., Bryant, E., Byrne, S., Caldwell, B., Calvert, S., Carroll, B., Castle, D., ... et al, A. (2022). Psychiatric and medical comorbidities of eating disorders : findings from a rapid review of the literature. Journal of Eating Disorders, 10(1), Article 132. https://doi.org/10.1186/s40337-022-00654-2

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title = "Psychiatric and medical comorbidities of eating disorders : findings from a rapid review of the literature",

abstract = "Background: Eating disorders (EDs) are potentially severe, complex, and life-threatening illnesses. The mortality rate of EDs is significantly elevated compared to other psychiatric conditions, primarily due to medical complications and suicide. The current rapid review aimed to summarise the literature and identify gaps in knowledge relating to any psychiatric and medical comorbidities of eating disorders. Methods: This paper forms part of a rapid review) series scoping the evidence base for the field of EDs, conducted to inform the Australian National Eating Disorders Research and Translation Strategy 2021–2031, funded and released by the Australian Government. ScienceDirect, PubMed and Ovid/Medline were searched for English-language studies focused on the psychiatric and medical comorbidities of EDs, published between 2009 and 2021. High-level evidence such as meta-analyses, large population studies and Randomised Control Trials were prioritised. Results: A total of 202 studies were included in this review, with 58\% pertaining to psychiatric comorbidities and 42\% to medical comorbidities. For EDs in general, the most prevalent psychiatric comorbidities were anxiety (up to 62\%), mood (up to 54\%) and substance use and post-traumatic stress disorders (similar comorbidity rates up to 27\%). The review also noted associations between specific EDs and non-suicidal self-injury, personality disorders, and neurodevelopmental disorders. EDs were complicated by medical comorbidities across the neuroendocrine, skeletal, nutritional, gastrointestinal, dental, and reproductive systems. Medical comorbidities can precede, occur alongside or emerge as a complication of the ED. Conclusions: This review provides a thorough overview of the comorbid psychiatric and medical conditions co-occurring with EDs. High psychiatric and medical comorbidity rates were observed in people with EDs, with comorbidities contributing to increased ED symptom severity, maintenance of some ED behaviours, and poorer functioning as well as treatment outcomes. Early identification and management of psychiatric and medical comorbidities in people with an ED may improve response to treatment and overall outcomes.",

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year = "2022",

month = dec,

doi = "10.1186/s40337-022-00654-2",

language = "English",

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Hambleton, A, Pepin, G, Le, A, Maloney, D, Touyz, S, Maguire, S, National Eating Disorder Research Consortium, , Conti, J , Hay, P, Aouad, P, Barakat, S, Boakes, R, Brennan, L, Bryant, E, Byrne, S, Caldwell, B, Calvert, S, Carroll, B, Castle, D, Caterson, I, Chelius, B, Chiem, L, Clarke, S, Crouch, L, Dammery, G, Dzajkovski, N, Fardouly, J, Felicia, C, Feneley, J, Firriolo, A-M, Foroughi, N, Fuller-Tyszkiewicz, M, Fursland, A, Gonzalez-Arce, V, Gouldthorp, B, Grifn, K, Grifths, S, Hannigan, A, Hart, M, Hart, S, Hickie, I, Kay-Lambkin, F, King, R, Kohn, M, Koreshe, E, Krug, I, Linardon, J, Long, R, Long, A, Madden, S & et al, A 2022, 'Psychiatric and medical comorbidities of eating disorders : findings from a rapid review of the literature', Journal of Eating Disorders, vol. 10, no. 1, 132. https://doi.org/10.1186/s40337-022-00654-2

TY - JOUR

T1 - Psychiatric and medical comorbidities of eating disorders : findings from a rapid review of the literature

AU - Hambleton, Ashlea

AU - Pepin, Genevieve

AU - Le, Anvi

AU - Maloney, Danielle

AU - Touyz, Stephen

AU - Maguire, Sarah

AU - National Eating Disorder Research Consortium, null

AU - Conti, Janet

AU - Hay, Phillipa

AU - Aouad, Phillip

AU - Barakat, Sarah

AU - Boakes, Robert

AU - Brennan, Leah

AU - Bryant, Emma

AU - Byrne, Susan

AU - Caldwell, Belinda

AU - Calvert, Shannon

AU - Carroll, Bronny

AU - Castle, David

AU - Caterson, Ian

AU - Chelius, Belinda

AU - Chiem, Lyn

AU - Clarke, Simon

AU - Crouch, Lexi

AU - Dammery, Genevieve

AU - Dzajkovski, Natasha

AU - Fardouly, Jasmine

AU - Felicia, Carmen

AU - Feneley, John

AU - Firriolo, Amber-Marie

AU - Foroughi, Nasim

AU - Fuller-Tyszkiewicz, Mathew

AU - Fursland, Anthea

AU - Gonzalez-Arce, Veronica

AU - Gouldthorp, Bethanie

AU - Grifn, Kelly

AU - Grifths, Scott

AU - Hannigan, Amy

AU - Hart, Mel

AU - Hart, Susan

AU - Hickie, Ian

AU - Kay-Lambkin, Francis

AU - King, Ross

AU - Kohn, Michael

AU - Koreshe, Eyza

AU - Krug, Isabel

AU - Linardon, Jake

AU - Long, Randall

AU - Long, Amanda

AU - Madden, Sloane

AU - et al, al

PY - 2022/12

Y1 - 2022/12

N2 - Background: Eating disorders (EDs) are potentially severe, complex, and life-threatening illnesses. The mortality rate of EDs is significantly elevated compared to other psychiatric conditions, primarily due to medical complications and suicide. The current rapid review aimed to summarise the literature and identify gaps in knowledge relating to any psychiatric and medical comorbidities of eating disorders. Methods: This paper forms part of a rapid review) series scoping the evidence base for the field of EDs, conducted to inform the Australian National Eating Disorders Research and Translation Strategy 2021–2031, funded and released by the Australian Government. ScienceDirect, PubMed and Ovid/Medline were searched for English-language studies focused on the psychiatric and medical comorbidities of EDs, published between 2009 and 2021. High-level evidence such as meta-analyses, large population studies and Randomised Control Trials were prioritised. Results: A total of 202 studies were included in this review, with 58% pertaining to psychiatric comorbidities and 42% to medical comorbidities. For EDs in general, the most prevalent psychiatric comorbidities were anxiety (up to 62%), mood (up to 54%) and substance use and post-traumatic stress disorders (similar comorbidity rates up to 27%). The review also noted associations between specific EDs and non-suicidal self-injury, personality disorders, and neurodevelopmental disorders. EDs were complicated by medical comorbidities across the neuroendocrine, skeletal, nutritional, gastrointestinal, dental, and reproductive systems. Medical comorbidities can precede, occur alongside or emerge as a complication of the ED. Conclusions: This review provides a thorough overview of the comorbid psychiatric and medical conditions co-occurring with EDs. High psychiatric and medical comorbidity rates were observed in people with EDs, with comorbidities contributing to increased ED symptom severity, maintenance of some ED behaviours, and poorer functioning as well as treatment outcomes. Early identification and management of psychiatric and medical comorbidities in people with an ED may improve response to treatment and overall outcomes.

AB - Background: Eating disorders (EDs) are potentially severe, complex, and life-threatening illnesses. The mortality rate of EDs is significantly elevated compared to other psychiatric conditions, primarily due to medical complications and suicide. The current rapid review aimed to summarise the literature and identify gaps in knowledge relating to any psychiatric and medical comorbidities of eating disorders. Methods: This paper forms part of a rapid review) series scoping the evidence base for the field of EDs, conducted to inform the Australian National Eating Disorders Research and Translation Strategy 2021–2031, funded and released by the Australian Government. ScienceDirect, PubMed and Ovid/Medline were searched for English-language studies focused on the psychiatric and medical comorbidities of EDs, published between 2009 and 2021. High-level evidence such as meta-analyses, large population studies and Randomised Control Trials were prioritised. Results: A total of 202 studies were included in this review, with 58% pertaining to psychiatric comorbidities and 42% to medical comorbidities. For EDs in general, the most prevalent psychiatric comorbidities were anxiety (up to 62%), mood (up to 54%) and substance use and post-traumatic stress disorders (similar comorbidity rates up to 27%). The review also noted associations between specific EDs and non-suicidal self-injury, personality disorders, and neurodevelopmental disorders. EDs were complicated by medical comorbidities across the neuroendocrine, skeletal, nutritional, gastrointestinal, dental, and reproductive systems. Medical comorbidities can precede, occur alongside or emerge as a complication of the ED. Conclusions: This review provides a thorough overview of the comorbid psychiatric and medical conditions co-occurring with EDs. High psychiatric and medical comorbidity rates were observed in people with EDs, with comorbidities contributing to increased ED symptom severity, maintenance of some ED behaviours, and poorer functioning as well as treatment outcomes. Early identification and management of psychiatric and medical comorbidities in people with an ED may improve response to treatment and overall outcomes.

UR - https://hdl.handle.net/1959.7/uws:67834

U2 - 10.1186/s40337-022-00654-2

DO - 10.1186/s40337-022-00654-2

M3 - Article

SN - 2050-2974

VL - 10

JO - Journal of Eating Disorders

JF - Journal of Eating Disorders

IS - 1

M1 - 132

ER -

Psychiatric and medical comorbidities of eating disorders : findings from a rapid review of the literature

Abstract

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