Putative biomarker of working memory systems development during childhood and adolescence

Hannah A.D. Keage; Christopher R. Clark; Daniel F. Hermens; Leanne M. Williams; Michael R. Kohn; Simon Clarke; Christopher Lamb; David Crewther; Evian Gordon

doi:10.1097/WNR.0b013e3282f454af

Putative biomarker of working memory systems development during childhood and adolescence

Hannah A.D. Keage, Christopher R. Clark, Daniel F. Hermens, Leanne M. Williams, Michael R. Kohn, Simon Clarke, Christopher Lamb, David Crewther, Evian Gordon

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The study aimed to identify brain functional indicators of working memory systems development between 6 and 18 years. Event-related potentials (ERPs) were recorded from 251 normally developing children to stimuli requiring the updating of working memory. Cluster analysis of event-related potential componentry divided the sample into three clusters (mean ages 9, 12 and 16 years), with ascending cluster membership independently associated with improved task performance. The clusters correspond to periods of grey matter loss and white matter increase observed in developing children, supporting the view that the clusters delineate three key qualitative stages in advancing cognitive capability during the maturation of higher brain systems function. This outcome identifies a biomarker with the potential for assessing abnormalities in the rate of brain development.

Original language	English
Pages (from-to)	197-201
Number of pages	5
Journal	NeuroReport
Volume	19
Issue number	2
DOIs	https://doi.org/10.1097/WNR.0b013e3282f454af
Publication status	Published - Jan 2008
Externally published	Yes

Keywords

Cognitive development
Event-related potential
Working memory

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10.1097/WNR.0b013e3282f454af

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abstract = "The study aimed to identify brain functional indicators of working memory systems development between 6 and 18 years. Event-related potentials (ERPs) were recorded from 251 normally developing children to stimuli requiring the updating of working memory. Cluster analysis of event-related potential componentry divided the sample into three clusters (mean ages 9, 12 and 16 years), with ascending cluster membership independently associated with improved task performance. The clusters correspond to periods of grey matter loss and white matter increase observed in developing children, supporting the view that the clusters delineate three key qualitative stages in advancing cognitive capability during the maturation of higher brain systems function. This outcome identifies a biomarker with the potential for assessing abnormalities in the rate of brain development.",

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AU - Keage, Hannah A.D.

AU - Clark, Christopher R.

AU - Hermens, Daniel F.

AU - Williams, Leanne M.

AU - Kohn, Michael R.

AU - Clarke, Simon

AU - Lamb, Christopher

AU - Crewther, David

AU - Gordon, Evian

PY - 2008/1

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Putative biomarker of working memory systems development during childhood and adolescence

Abstract

Keywords

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