TY - JOUR
T1 - Quality of life in chronic NSAID users : a comparison of the effect of omeprazole and misoprostol
AU - Yeomans, Neville D.
AU - Wilson, Ingalill
AU - Langstrom, Goran
AU - Hawkey, Christopher J.
AU - Naesdal, Jorgen
AU - Walan, Anders
AU - Wikland, Ingela
PY - 2001
Y1 - 2001
N2 - Objective : To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. Methods : Validated baseline and follow-up QoL questionnaires were completed by 610 patients (healing: after 4/8 weeks; maintenance: after 6 months). Results : Patients with arthritis being treated with NSAIDs have a poor QoL. Rheumatoid arthritis causes more joint problems and physical mobility limitations than osteoarthritis. Chronic NSAID use causes heartburn and dyspepsia. QoL improved on both treatments (about equally on two general QOL scales), but omeprazole relieved gastrointestinal symptoms more than misoprostol, particularly reflux, abdominal pain and indigestion symptoms. During maintenance, both treatments maintained QoL, but misoprostol induced diarrhoea. Conclusion : QoL in arthritis patients on chronic NSAID treatment is destroyed. Omeprazole is superior to misoprostol for relief and prevention of NSAID-associated gastrointestinal symptoms allowing continued NSAID treatment without compromising the patients' QoL.
AB - Objective : To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. Methods : Validated baseline and follow-up QoL questionnaires were completed by 610 patients (healing: after 4/8 weeks; maintenance: after 6 months). Results : Patients with arthritis being treated with NSAIDs have a poor QoL. Rheumatoid arthritis causes more joint problems and physical mobility limitations than osteoarthritis. Chronic NSAID use causes heartburn and dyspepsia. QoL improved on both treatments (about equally on two general QOL scales), but omeprazole relieved gastrointestinal symptoms more than misoprostol, particularly reflux, abdominal pain and indigestion symptoms. During maintenance, both treatments maintained QoL, but misoprostol induced diarrhoea. Conclusion : QoL in arthritis patients on chronic NSAID treatment is destroyed. Omeprazole is superior to misoprostol for relief and prevention of NSAID-associated gastrointestinal symptoms allowing continued NSAID treatment without compromising the patients' QoL.
KW - Misoprostol
KW - Omeprazole
KW - heartburn
KW - nonsteroidal anti-inflammatory agents
KW - quality of life
KW - rheumatoid arthritis
UR - http://handle.uws.edu.au:8081/1959.7/34792
U2 - 10.1080/030097401317148516
DO - 10.1080/030097401317148516
M3 - Article
SN - 0300-9742
SP - 328
EP - 334
JO - Scandinavian Journal of Rheumatology
JF - Scandinavian Journal of Rheumatology
ER -