Reactive species and their accumulation on radical-damaged proteins

Roger T. Dean; Steven Gieseg; Michael J. Davies

doi:10.1016/0968-0004(93)90145-D

Reactive species and their accumulation on radical-damaged proteins

Roger T. Dean, Steven Gieseg, Michael J. Davies

Research output: Contribution to journal › Article › peer-review

241 Citations (Scopus)

Abstract

Hydroperoxides and catechols are described as novel reactive products of radical attack on proteins. These species, like other components of oxidized and otherwise damaged proteins, may accumulate in some biological systems. We propose that the reactive species may then attack other biomolecules, and constitute both a marker and a mechanism of age-related pathologies.

Original language	English
Pages (from-to)	437-441
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	18
Issue number	11
DOIs	https://doi.org/10.1016/0968-0004(93)90145-D
Publication status	Published - Nov 1993
Externally published	Yes

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10.1016/0968-0004(93)90145-D

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title = "Reactive species and their accumulation on radical-damaged proteins",

abstract = "Hydroperoxides and catechols are described as novel reactive products of radical attack on proteins. These species, like other components of oxidized and otherwise damaged proteins, may accumulate in some biological systems. We propose that the reactive species may then attack other biomolecules, and constitute both a marker and a mechanism of age-related pathologies.",

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AB - Hydroperoxides and catechols are described as novel reactive products of radical attack on proteins. These species, like other components of oxidized and otherwise damaged proteins, may accumulate in some biological systems. We propose that the reactive species may then attack other biomolecules, and constitute both a marker and a mechanism of age-related pathologies.

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Reactive species and their accumulation on radical-damaged proteins

Abstract

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