TY - JOUR
T1 - Relationships among cognitive function and cerebral blood flow, oxidative stress, and inflammation in older heart failure patients
AU - Kure, Christina E.
AU - Rosenfeldt, Franklin L.
AU - Scholey, Andrew B.
AU - Pipingas, Andrew
AU - Kaye, David M.
AU - Bergin, Peter J.
AU - Croft, Kevin D.
AU - Wesnes, Keith A.
AU - Myers, Stephen P.
AU - Stough, Con
PY - 2016
Y1 - 2016
N2 - Background: The mechanisms for cognitive impairment in heart failure (HF) are unclear. We investigated the relative contributions of cerebral blood flow velocity (BFV), oxidative stress, and inflammation to HF-associated cognitive impairment. Methods and Results: Thirty-six HF patients (>= 60 years) and 40 healthy controls (68 7 vs 67 5 years, P > .05; 69% vs 50% male, P > .05) completed the Cognitive Drug Research computerized assessment battery and Stroop tasks. Common carotid (CCA) and middle cerebral arterial BFV were obtained by transcranial Doppler. Blood samples were collected for oxidant (diacron-reactive oxygen metabolites; F-2-isoprostanes), antioxidant (coenzyme Q(10); CoQ(10)), and inflammatory markers (high-sensitivity C-reactive protein). Compared with controls, patients exhibited impaired attention (Cognitive Drug Research's Power of Attention domain, congruent Stroop) and executive function (incongruent Stroop). Multiple regression modeling showed that CCA-BFV and CoQ(10) but not group predicted performance on attention and executive function. Additionally, in HF patients, CCA-BFV and CoQ(10) (beta = -0.34 vs beta = -0.35) were significant predictors of attention, and CCA-BFV (beta = -0.34) was a predictor of executive function. Conclusions: Power of Attention and executive function is impaired in older HF patients, and reduced CCA-BFV and CoQ(10) are associated with worse cognition. Interventions addressing these mechanisms may improve cognition in older HF patients.
AB - Background: The mechanisms for cognitive impairment in heart failure (HF) are unclear. We investigated the relative contributions of cerebral blood flow velocity (BFV), oxidative stress, and inflammation to HF-associated cognitive impairment. Methods and Results: Thirty-six HF patients (>= 60 years) and 40 healthy controls (68 7 vs 67 5 years, P > .05; 69% vs 50% male, P > .05) completed the Cognitive Drug Research computerized assessment battery and Stroop tasks. Common carotid (CCA) and middle cerebral arterial BFV were obtained by transcranial Doppler. Blood samples were collected for oxidant (diacron-reactive oxygen metabolites; F-2-isoprostanes), antioxidant (coenzyme Q(10); CoQ(10)), and inflammatory markers (high-sensitivity C-reactive protein). Compared with controls, patients exhibited impaired attention (Cognitive Drug Research's Power of Attention domain, congruent Stroop) and executive function (incongruent Stroop). Multiple regression modeling showed that CCA-BFV and CoQ(10) but not group predicted performance on attention and executive function. Additionally, in HF patients, CCA-BFV and CoQ(10) (beta = -0.34 vs beta = -0.35) were significant predictors of attention, and CCA-BFV (beta = -0.34) was a predictor of executive function. Conclusions: Power of Attention and executive function is impaired in older HF patients, and reduced CCA-BFV and CoQ(10) are associated with worse cognition. Interventions addressing these mechanisms may improve cognition in older HF patients.
UR - https://hdl.handle.net/1959.7/uws:64300
U2 - 10.1016/j.cardfail.2016.03.006
DO - 10.1016/j.cardfail.2016.03.006
M3 - Article
SN - 1071-9164
VL - 22
SP - 548
EP - 559
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 7
ER -