Research priorities on physical-mental comorbidity in children and adolescents: an international consensus

Denan Jiang; Jiali Zhou; Yajie Zhu; Edimansyah Abdin; Tracie O. Afifi; Laura Helena S.G. Andrade; Rebecca Bendayan; Emma E. Berkelbach van der Sprenkel; Ronny Bruffaerts; Ferrán Catalá-López; Ian Colman; Benjamin G. Druss; Laura Duncan; Nuša Farič; Erika Felix; Holly Foster; Shurong Lu; Hassan Mansour; Ruth Ann Marrie; Tanya Meade; Salima Meherali; Carles Muntaner; Yoko Nomura; Junko Okuyama; Susan J. Rees; Graham J. Reid; Janet U. Schneiderman; Dan J. Stein; Frederick W. Thielen; Wan Yee Winnie Tso; André Oliveira Werneck; Xiaoyan Wu; Igor Rudan; Peige Song

doi:10.1016/j.eclinm.2025.103559

Research priorities on physical-mental comorbidity in children and adolescents: an international consensus

Denan Jiang
, Jiali Zhou
, Yajie Zhu
, Edimansyah Abdin
, Tracie O. Afifi
, Laura Helena S.G. Andrade
, Rebecca Bendayan
, Emma E. Berkelbach van der Sprenkel
, Ronny Bruffaerts
, Ferrán Catalá-López
, Ian Colman
, Benjamin G. Druss
, Laura Duncan
, Nuša Farič
, Erika Felix
, Holly Foster
, Shurong Lu
, Hassan Mansour
, Ruth Ann Marrie
, Tanya Meade

Salima Meherali, Carles Muntaner, Yoko Nomura, Junko Okuyama, Susan J. Rees, Graham J. Reid, Janet U. Schneiderman, Dan J. Stein, Frederick W. Thielen, Wan Yee Winnie Tso, André Oliveira Werneck, Xiaoyan Wu, Igor Rudan, Peige Song

School of Psychology

Zhejiang University
Hangzhou Normal University
Singapore Institute of Mental Health
University of Manitoba
Universidade de São Paulo
King's College London
South London and Maudsley NHS Foundation Trust
Utrecht University
KU Leuven
CSIC - Center for Human and Social Sciences
University of Ottawa
Emory University
McMaster University
McMaster Children's Hospital
University of Edinburgh
University of California at Santa Barbara
Texas A&M University
University of Melbourne
North London NHS Foundation Trust
Dalhousie University
Nova Scotia Health
University of Alberta
University of Toronto
Johns Hopkins University
Pompeu Fabra University
City University of New York
Icahn School of Medicine at Mount Sinai
Shokei Gakuin University
University of New South Wales
Children's Health Research Institute
University of Western Ontario
Lawson Health Research Institute
University of Southern California
University of Cape Town
Erasmus University Rotterdam
Trimbos Institute, Netherlands Institute of Mental Health and Addiction
The University of Hong Kong
Anhui Medical University
University of Oxford

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

2 Downloads (Pure)

Abstract

Physical-mental comorbidity in children and adolescents is an emerging global health concern, yet research remains fragmented and lacks a coordinated agenda. We conducted a global priority setting exercise using the Child Health and Nutrition Research Initiative method. A total of 134 research ideas were scored by 45 experts against five criteria: answerability, effectiveness, potential for paradigm shift, potential for translation and implementation, and impact on equity. The highest-ranked priorities focused on treatment strategies, early intervention, reducing disparities in care, and the role of schools and communities in supporting health. Comparative analyses revealed both shared and context-specific needs across income settings. This is the first global consensus on research priorities for child and adolescent physical-mental comorbidity and offers a strategic roadmap to guide future research and policy.

Original language	English
Article number	103559
Number of pages	13
Journal	EClinicalMedicine
Volume	89
DOIs	https://doi.org/10.1016/j.eclinm.2025.103559
Publication status	Published - Nov 2025

Open Access - Access Right Statement

Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

Child and adolescent health
Global health
Physical-mental comorbidity
Research prioritization

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10.1016/j.eclinm.2025.103559Licence: CC BY-NC-ND

Full textFinal published version, 2.78 MBLicence: CC BY-NC-ND

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Jiang, D., Zhou, J., Zhu, Y., Abdin, E., Afifi, T. O., Andrade, L. H. S. G., Bendayan, R., Berkelbach van der Sprenkel, E. E., Bruffaerts, R., Catalá-López, F., Colman, I., Druss, B. G., Duncan, L., Farič, N., Felix, E., Foster, H., Lu, S., Mansour, H., Marrie, R. A., ... Song, P. (2025). Research priorities on physical-mental comorbidity in children and adolescents: an international consensus. EClinicalMedicine, 89, Article 103559. https://doi.org/10.1016/j.eclinm.2025.103559

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title = "Research priorities on physical-mental comorbidity in children and adolescents: an international consensus",

abstract = "Physical-mental comorbidity in children and adolescents is an emerging global health concern, yet research remains fragmented and lacks a coordinated agenda. We conducted a global priority setting exercise using the Child Health and Nutrition Research Initiative method. A total of 134 research ideas were scored by 45 experts against five criteria: answerability, effectiveness, potential for paradigm shift, potential for translation and implementation, and impact on equity. The highest-ranked priorities focused on treatment strategies, early intervention, reducing disparities in care, and the role of schools and communities in supporting health. Comparative analyses revealed both shared and context-specific needs across income settings. This is the first global consensus on research priorities for child and adolescent physical-mental comorbidity and offers a strategic roadmap to guide future research and policy.",

keywords = "Child and adolescent health, Global health, Physical-mental comorbidity, Research prioritization",

author = "Denan Jiang and Jiali Zhou and Yajie Zhu and Edimansyah Abdin and Afifi, \{Tracie O.\} and Andrade, \{Laura Helena S.G.\} and Rebecca Bendayan and \{Berkelbach van der Sprenkel\}, \{Emma E.\} and Ronny Bruffaerts and Ferr{\'a}n Catal{\'a}-L{\'o}pez and Ian Colman and Druss, \{Benjamin G.\} and Laura Duncan and Nu{\v s}a Fari{\v c} and Erika Felix and Holly Foster and Shurong Lu and Hassan Mansour and Marrie, \{Ruth Ann\} and Tanya Meade and Salima Meherali and Carles Muntaner and Yoko Nomura and Junko Okuyama and Rees, \{Susan J.\} and Reid, \{Graham J.\} and Schneiderman, \{Janet U.\} and Stein, \{Dan J.\} and Thielen, \{Frederick W.\} and Tso, \{Wan Yee Winnie\} and \{Oliveira Werneck\}, Andr{\'e} and Xiaoyan Wu and Igor Rudan and Peige Song",

year = "2025",

month = nov,

doi = "10.1016/j.eclinm.2025.103559",

language = "English",

volume = "89",

journal = "EClinicalMedicine",

issn = "2589-5370",

publisher = "Elsevier Ltd.",

}

Jiang, D, Zhou, J, Zhu, Y, Abdin, E, Afifi, TO, Andrade, LHSG, Bendayan, R, Berkelbach van der Sprenkel, EE, Bruffaerts, R, Catalá-López, F, Colman, I, Druss, BG, Duncan, L, Farič, N, Felix, E, Foster, H, Lu, S, Mansour, H, Marrie, RA, Meade, T, Meherali, S, Muntaner, C, Nomura, Y, Okuyama, J, Rees, SJ, Reid, GJ, Schneiderman, JU, Stein, DJ, Thielen, FW, Tso, WYW, Oliveira Werneck, A, Wu, X, Rudan, I & Song, P 2025, 'Research priorities on physical-mental comorbidity in children and adolescents: an international consensus', EClinicalMedicine, vol. 89, 103559. https://doi.org/10.1016/j.eclinm.2025.103559

TY - JOUR

T1 - Research priorities on physical-mental comorbidity in children and adolescents

T2 - an international consensus

AU - Jiang, Denan

AU - Zhou, Jiali

AU - Zhu, Yajie

AU - Abdin, Edimansyah

AU - Afifi, Tracie O.

AU - Andrade, Laura Helena S.G.

AU - Bendayan, Rebecca

AU - Berkelbach van der Sprenkel, Emma E.

AU - Bruffaerts, Ronny

AU - Catalá-López, Ferrán

AU - Colman, Ian

AU - Druss, Benjamin G.

AU - Duncan, Laura

AU - Farič, Nuša

AU - Felix, Erika

AU - Foster, Holly

AU - Lu, Shurong

AU - Mansour, Hassan

AU - Marrie, Ruth Ann

AU - Meade, Tanya

AU - Meherali, Salima

AU - Muntaner, Carles

AU - Nomura, Yoko

AU - Okuyama, Junko

AU - Rees, Susan J.

AU - Reid, Graham J.

AU - Schneiderman, Janet U.

AU - Stein, Dan J.

AU - Thielen, Frederick W.

AU - Tso, Wan Yee Winnie

AU - Oliveira Werneck, André

AU - Wu, Xiaoyan

AU - Rudan, Igor

AU - Song, Peige

PY - 2025/11

Y1 - 2025/11

N2 - Physical-mental comorbidity in children and adolescents is an emerging global health concern, yet research remains fragmented and lacks a coordinated agenda. We conducted a global priority setting exercise using the Child Health and Nutrition Research Initiative method. A total of 134 research ideas were scored by 45 experts against five criteria: answerability, effectiveness, potential for paradigm shift, potential for translation and implementation, and impact on equity. The highest-ranked priorities focused on treatment strategies, early intervention, reducing disparities in care, and the role of schools and communities in supporting health. Comparative analyses revealed both shared and context-specific needs across income settings. This is the first global consensus on research priorities for child and adolescent physical-mental comorbidity and offers a strategic roadmap to guide future research and policy.

AB - Physical-mental comorbidity in children and adolescents is an emerging global health concern, yet research remains fragmented and lacks a coordinated agenda. We conducted a global priority setting exercise using the Child Health and Nutrition Research Initiative method. A total of 134 research ideas were scored by 45 experts against five criteria: answerability, effectiveness, potential for paradigm shift, potential for translation and implementation, and impact on equity. The highest-ranked priorities focused on treatment strategies, early intervention, reducing disparities in care, and the role of schools and communities in supporting health. Comparative analyses revealed both shared and context-specific needs across income settings. This is the first global consensus on research priorities for child and adolescent physical-mental comorbidity and offers a strategic roadmap to guide future research and policy.

KW - Child and adolescent health

KW - Global health

KW - Physical-mental comorbidity

KW - Research prioritization

UR - https://www.scopus.com/pages/publications/105019212811

U2 - 10.1016/j.eclinm.2025.103559

DO - 10.1016/j.eclinm.2025.103559

M3 - Article

AN - SCOPUS:105019212811

SN - 2589-5370

VL - 89

JO - EClinicalMedicine

JF - EClinicalMedicine

M1 - 103559

ER -

Research priorities on physical-mental comorbidity in children and adolescents: an international consensus

Abstract

Open Access - Access Right Statement

Keywords

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