Rewilding immunology : integrating comparative immunology can improve human, animal, and ecosystem health

Andrew S. Flies; Jerome Le Nours; Ruth J. Pye; Lee F. Skerratt; Laura F. Grogan; Kirsty R. Short; Nicholas M. Fountain-Jones; Julie M. Old; Anthony W. Waddle; Anne Peters; Camila Espejo; Amanda L. Patchett; Terry L. Pinfold; Sarah Shigdar; Jamie Rossjohn; Oselyne Ong; Michelle Power; Michelle L. Baker

doi:10.1126/science.abb8664

Rewilding immunology : integrating comparative immunology can improve human, animal, and ecosystem health

Andrew S. Flies, Jerome Le Nours, Ruth J. Pye, Lee F. Skerratt, Laura F. Grogan, Kirsty R. Short, Nicholas M. Fountain-Jones, Julie M. Old, Anthony W. Waddle, Anne Peters, Camila Espejo, Amanda L. Patchett, Terry L. Pinfold, Sarah Shigdar, Jamie Rossjohn, Oselyne Ong, Michelle Power, Michelle L. Baker

Western Sydney University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The common origin of all species provides a wealth of history recorded in DNA and a lens for understanding human biology. Immunology research has traditionally used rodents as the model of choice. However, translational success has not met its full potential. Broadening immunology research to integrate comparative approaches across species and environments can amplify the potential of immunology to improve the lives of humans and other animals. Additionally, it can lead to discoveries that are not possible in a restricted set of model organisms and environments. For example, the contemporary vaccine era arose from observing human-animal interactions in a real-world environment (cowpox infection protected milkmaids from smallpox). Most emerging infectious diseases (EIDs) originate in domestic and wild animals (1), and the coronavirus disease 2019 (COVID-19) pandemic is a stark reminder of the need to think more holistically about the health of humans and animals.

Original language	English
Pages (from-to)	37-38
Number of pages	2
Journal	Science
Volume	369
Issue number	6499
DOIs	https://doi.org/10.1126/science.abb8664
Publication status	Published - 2020

Keywords

communicable diseases
domestic animals
genomes
immunology
research
wild animals

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Flies, A. S., Le Nours, J., Pye, R. J., Skerratt, L. F., Grogan, L. F., Short, K. R., Fountain-Jones, N. M., Old, J. M., Waddle, A. W., Peters, A., Espejo, C., Patchett, A. L., Pinfold, T. L., Shigdar, S., Rossjohn, J., Ong, O., Power, M., & Baker, M. L. (2020). Rewilding immunology : integrating comparative immunology can improve human, animal, and ecosystem health. Science, 369(6499), 37-38. https://doi.org/10.1126/science.abb8664

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title = "Rewilding immunology : integrating comparative immunology can improve human, animal, and ecosystem health",

abstract = "The common origin of all species provides a wealth of history recorded in DNA and a lens for understanding human biology. Immunology research has traditionally used rodents as the model of choice. However, translational success has not met its full potential. Broadening immunology research to integrate comparative approaches across species and environments can amplify the potential of immunology to improve the lives of humans and other animals. Additionally, it can lead to discoveries that are not possible in a restricted set of model organisms and environments. For example, the contemporary vaccine era arose from observing human-animal interactions in a real-world environment (cowpox infection protected milkmaids from smallpox). Most emerging infectious diseases (EIDs) originate in domestic and wild animals (1), and the coronavirus disease 2019 (COVID-19) pandemic is a stark reminder of the need to think more holistically about the health of humans and animals.",

keywords = "communicable diseases, domestic animals, genomes, immunology, research, wild animals",

author = "Flies, {Andrew S.} and {Le Nours}, Jerome and Pye, {Ruth J.} and Skerratt, {Lee F.} and Grogan, {Laura F.} and Short, {Kirsty R.} and Fountain-Jones, {Nicholas M.} and Old, {Julie M.} and Waddle, {Anthony W.} and Anne Peters and Camila Espejo and Patchett, {Amanda L.} and Pinfold, {Terry L.} and Sarah Shigdar and Jamie Rossjohn and Oselyne Ong and Michelle Power and Baker, {Michelle L.}",

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doi = "10.1126/science.abb8664",

language = "English",

volume = "369",

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Flies, AS, Le Nours, J, Pye, RJ, Skerratt, LF, Grogan, LF, Short, KR, Fountain-Jones, NM, Old, JM, Waddle, AW, Peters, A, Espejo, C, Patchett, AL, Pinfold, TL, Shigdar, S, Rossjohn, J, Ong, O, Power, M & Baker, ML 2020, 'Rewilding immunology : integrating comparative immunology can improve human, animal, and ecosystem health', Science, vol. 369, no. 6499, pp. 37-38. https://doi.org/10.1126/science.abb8664

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AU - Flies, Andrew S.

AU - Le Nours, Jerome

AU - Pye, Ruth J.

AU - Skerratt, Lee F.

AU - Grogan, Laura F.

AU - Short, Kirsty R.

AU - Fountain-Jones, Nicholas M.

AU - Old, Julie M.

AU - Waddle, Anthony W.

AU - Peters, Anne

AU - Espejo, Camila

AU - Patchett, Amanda L.

AU - Pinfold, Terry L.

AU - Shigdar, Sarah

AU - Rossjohn, Jamie

AU - Ong, Oselyne

AU - Power, Michelle

AU - Baker, Michelle L.

PY - 2020

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AB - The common origin of all species provides a wealth of history recorded in DNA and a lens for understanding human biology. Immunology research has traditionally used rodents as the model of choice. However, translational success has not met its full potential. Broadening immunology research to integrate comparative approaches across species and environments can amplify the potential of immunology to improve the lives of humans and other animals. Additionally, it can lead to discoveries that are not possible in a restricted set of model organisms and environments. For example, the contemporary vaccine era arose from observing human-animal interactions in a real-world environment (cowpox infection protected milkmaids from smallpox). Most emerging infectious diseases (EIDs) originate in domestic and wild animals (1), and the coronavirus disease 2019 (COVID-19) pandemic is a stark reminder of the need to think more holistically about the health of humans and animals.

KW - communicable diseases

KW - domestic animals

KW - genomes

KW - immunology

KW - research

KW - wild animals

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U2 - 10.1126/science.abb8664

DO - 10.1126/science.abb8664

M3 - Article

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VL - 369

SP - 37

EP - 38

JO - Science

JF - Science

IS - 6499

ER -

Rewilding immunology : integrating comparative immunology can improve human, animal, and ecosystem health

Abstract

Keywords

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