TY - JOUR
T1 - Risk factors and prognosis of postpericardiotomy syndrome in patients undergoing valve surgery
AU - van Osch, Dirk
AU - Dieleman, Jan M.
AU - Bunge, Jeroen J.
AU - van Dijk, Diederik
AU - Doevendans, Pieter A.
AU - Suyker, Willem J.
AU - Nathoe, Hendrik M.
AU - Bredée, Jaap J.
AU - Buhre, Wolfgang F.
AU - van Herwerden, Lex A.
AU - Kalkman, Cor J.
AU - van Klarenbosch, Jan
AU - Moons, Karel G.
AU - Numan, Sandra C.
AU - Ottens, Thomas H.
AU - Roes, Kit C.
AU - Sauer, Anne-Mette
AU - Slooter, Arjen J.
AU - Jacob, Kirolos A.
AU - Nierich, Arno P.
AU - Ennema, Jacob J.
AU - Rosseel, Peter M.
AU - van der Meer, Nardo J.
AU - van der Maaten, Joost M.
AU - Cernak, Vlado
AU - Hofland, Jan
AU - van Thiel, Robert J.
AU - Diephuis, Jan C.
AU - Schepp, Ronald M.
AU - Haenen, Jo
AU - de Lange, Fellery
AU - Boer, Christa
AU - de Jong, Jan R.
AU - Tijssen, Jan G.
PY - 2017
Y1 - 2017
N2 - Objective: The study aim was to investigate the long-term prognosis and risk factors of postpericardiotomy syndrome (PPS). Methods: We performed a single-center cohort study in 822 patients undergoing nonemergent valve surgery. Risk factors of PPS were evaluated using multivariable logistic regression analysis. We also compared the incidence of reoperation for tamponade at 1 year between patients with and without PPS. Main secondary outcomes were hospital stay and mortality. Results: Of the 822 patients, 119 (14.5%) developed PPS. A higher body mass index (odds ratio (OR) per point increase, 0.94; 95% confidence interval (CI), 0.89-0.99) was associated with a lower risk of PPS, whereas preoperative treatment for pulmonary disease without corticosteroids (OR, 2.55; 95% CI, 1.25-5.20) was associated with a higher risk of PPS. The incidence of reoperation for tamponade at 1 year in PPS versus no PPS was 20.9% versus 2.5% (OR, 15.49; 95% CI, 7.14-33.58). One-year mortality in PPS versus no PPS was 4.2% versus 5.5% (OR, 0.68; 95% CI, 0.22-2.08). Median hospital stay was 13 days (interquartile range, 9-18 days) versus 11 days (interquartile range, 8-15 days) (P ¼ .001), respectively. Conclusions: Despite longer hospital stays and more short-term reoperations for tamponade, patients with PPS had an excellent 1-year prognosis.
AB - Objective: The study aim was to investigate the long-term prognosis and risk factors of postpericardiotomy syndrome (PPS). Methods: We performed a single-center cohort study in 822 patients undergoing nonemergent valve surgery. Risk factors of PPS were evaluated using multivariable logistic regression analysis. We also compared the incidence of reoperation for tamponade at 1 year between patients with and without PPS. Main secondary outcomes were hospital stay and mortality. Results: Of the 822 patients, 119 (14.5%) developed PPS. A higher body mass index (odds ratio (OR) per point increase, 0.94; 95% confidence interval (CI), 0.89-0.99) was associated with a lower risk of PPS, whereas preoperative treatment for pulmonary disease without corticosteroids (OR, 2.55; 95% CI, 1.25-5.20) was associated with a higher risk of PPS. The incidence of reoperation for tamponade at 1 year in PPS versus no PPS was 20.9% versus 2.5% (OR, 15.49; 95% CI, 7.14-33.58). One-year mortality in PPS versus no PPS was 4.2% versus 5.5% (OR, 0.68; 95% CI, 0.22-2.08). Median hospital stay was 13 days (interquartile range, 9-18 days) versus 11 days (interquartile range, 8-15 days) (P ¼ .001), respectively. Conclusions: Despite longer hospital stays and more short-term reoperations for tamponade, patients with PPS had an excellent 1-year prognosis.
UR - http://hdl.handle.net/1959.7/uws:60757
U2 - 10.1016/j.jtcvs.2016.10.075
DO - 10.1016/j.jtcvs.2016.10.075
M3 - Article
SN - 0022-5223
VL - 153
SP - 878
EP - 885
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 4
ER -
