TY - JOUR
T1 - Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification
AU - Bobryshev, Yuri V.
AU - Orekhov, Alexander N.
AU - Sobenin, Igor
AU - Chistiakov, Dimitry A.
PY - 2014
Y1 - 2014
N2 - Matrix vesicle (MV)-mediated mineralization is important for bone ossification. However, under certain circumstances such as atherosclerosis, mineralization may occur in the arterial wall. Bone-type tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes inorganic pyrophosphate (PPi) and generates inorganic phosphate (Pi), which is essential for MV-mediated hydroxyapatite formation. MVs contain another phosphatase, PHOSPHO1, that serves as an additional supplier of Pi. Activation of bone-type tissue-nonspecific alkaline phosphatase (TNAP) in vascular smooth muscle cells precedes vascular calcification. By degrading PPi, TNAP plays a procalcific role changing the Pi/PPi ratio toward mineralization. A pathologic role of bone-type TNAP and PHOSPHO1 make them to be attractive targets for cardiovascular therapy.
AB - Matrix vesicle (MV)-mediated mineralization is important for bone ossification. However, under certain circumstances such as atherosclerosis, mineralization may occur in the arterial wall. Bone-type tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes inorganic pyrophosphate (PPi) and generates inorganic phosphate (Pi), which is essential for MV-mediated hydroxyapatite formation. MVs contain another phosphatase, PHOSPHO1, that serves as an additional supplier of Pi. Activation of bone-type tissue-nonspecific alkaline phosphatase (TNAP) in vascular smooth muscle cells precedes vascular calcification. By degrading PPi, TNAP plays a procalcific role changing the Pi/PPi ratio toward mineralization. A pathologic role of bone-type TNAP and PHOSPHO1 make them to be attractive targets for cardiovascular therapy.
KW - alkaline phosphatase
KW - atherosclerosis
KW - biomineralization
KW - vascular smooth muscle
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:42134
UR - https://www.researchgate.net/publication/264935219
M3 - Article
SN - 1381-6128
VL - 20
SP - 5821
EP - 5828
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 37
ER -