Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification

Yuri V. Bobryshev; Alexander N. Orekhov; Igor Sobenin; Dimitry A. Chistiakov

Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification

Yuri V. Bobryshev
, Alexander N. Orekhov
, Igor Sobenin
, Dimitry A. Chistiakov

Western Sydney University

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Matrix vesicle (MV)-mediated mineralization is important for bone ossification. However, under certain circumstances such as atherosclerosis, mineralization may occur in the arterial wall. Bone-type tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes inorganic pyrophosphate (PPi) and generates inorganic phosphate (Pi), which is essential for MV-mediated hydroxyapatite formation. MVs contain another phosphatase, PHOSPHO1, that serves as an additional supplier of Pi. Activation of bone-type tissue-nonspecific alkaline phosphatase (TNAP) in vascular smooth muscle cells precedes vascular calcification. By degrading PPi, TNAP plays a procalcific role changing the Pi/PPi ratio toward mineralization. A pathologic role of bone-type TNAP and PHOSPHO1 make them to be attractive targets for cardiovascular therapy.

Original language	English
Pages (from-to)	5821-5828
Number of pages	8
Journal	Current Pharmaceutical Design
Volume	20
Issue number	37
Publication status	Published - 2014

Keywords

alkaline phosphatase
atherosclerosis
biomineralization
vascular smooth muscle

Cite this

@article{904405eba7874054ab2f7015007fbb0e,

title = "Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification",

abstract = "Matrix vesicle (MV)-mediated mineralization is important for bone ossification. However, under certain circumstances such as atherosclerosis, mineralization may occur in the arterial wall. Bone-type tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes inorganic pyrophosphate (PPi) and generates inorganic phosphate (Pi), which is essential for MV-mediated hydroxyapatite formation. MVs contain another phosphatase, PHOSPHO1, that serves as an additional supplier of Pi. Activation of bone-type tissue-nonspecific alkaline phosphatase (TNAP) in vascular smooth muscle cells precedes vascular calcification. By degrading PPi, TNAP plays a procalcific role changing the Pi/PPi ratio toward mineralization. A pathologic role of bone-type TNAP and PHOSPHO1 make them to be attractive targets for cardiovascular therapy.",

keywords = "alkaline phosphatase, atherosclerosis, biomineralization, vascular smooth muscle",

author = "Bobryshev, \{Yuri V.\} and Orekhov, \{Alexander N.\} and Igor Sobenin and Chistiakov, \{Dimitry A.\}",

year = "2014",

language = "English",

volume = "20",

pages = "5821--5828",

journal = "Current Pharmaceutical Design",

issn = "1381-6128",

publisher = "Bentham Science Publishers",

number = "37",

}

TY - JOUR

T1 - Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification

AU - Bobryshev, Yuri V.

AU - Orekhov, Alexander N.

AU - Sobenin, Igor

AU - Chistiakov, Dimitry A.

PY - 2014

Y1 - 2014

N2 - Matrix vesicle (MV)-mediated mineralization is important for bone ossification. However, under certain circumstances such as atherosclerosis, mineralization may occur in the arterial wall. Bone-type tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes inorganic pyrophosphate (PPi) and generates inorganic phosphate (Pi), which is essential for MV-mediated hydroxyapatite formation. MVs contain another phosphatase, PHOSPHO1, that serves as an additional supplier of Pi. Activation of bone-type tissue-nonspecific alkaline phosphatase (TNAP) in vascular smooth muscle cells precedes vascular calcification. By degrading PPi, TNAP plays a procalcific role changing the Pi/PPi ratio toward mineralization. A pathologic role of bone-type TNAP and PHOSPHO1 make them to be attractive targets for cardiovascular therapy.

AB - Matrix vesicle (MV)-mediated mineralization is important for bone ossification. However, under certain circumstances such as atherosclerosis, mineralization may occur in the arterial wall. Bone-type tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes inorganic pyrophosphate (PPi) and generates inorganic phosphate (Pi), which is essential for MV-mediated hydroxyapatite formation. MVs contain another phosphatase, PHOSPHO1, that serves as an additional supplier of Pi. Activation of bone-type tissue-nonspecific alkaline phosphatase (TNAP) in vascular smooth muscle cells precedes vascular calcification. By degrading PPi, TNAP plays a procalcific role changing the Pi/PPi ratio toward mineralization. A pathologic role of bone-type TNAP and PHOSPHO1 make them to be attractive targets for cardiovascular therapy.

KW - alkaline phosphatase

KW - atherosclerosis

KW - biomineralization

KW - vascular smooth muscle

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:42134

UR - https://www.researchgate.net/publication/264935219

M3 - Article

SN - 1381-6128

VL - 20

SP - 5821

EP - 5828

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

IS - 37

ER -

Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification

Abstract

Keywords

Other files and links

Fingerprint

Cite this