Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications

Y. Jin, Y. Song, J. Lin, Tianqing Liu, G. Li, B. Lai, Y. Gu, G. Chen, L. Xing

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete loss of motor and sensory function. Massive neurons are damaged after the initial mechanical insult. Secondary injuries, which are triggered by immunological and inflammatory responses, also result in neuronal loss and axon retraction. This results in defects in the neural circuit and a deficiency in the processing of information. Although inflammatory responses are necessary for spinal cord recovery, conflicting evidence of their contributions to specific biological processes have made it difficult to define the specific role of inflammation in SCI. This review summarizes our understanding of the complex role of inflammation in neural circuit events following SCI, such as cell death, axon regeneration and neural remodeling. We also review the drugs that regulate immune responses and inflammation in the treatment of SCI and discuss the roles of these drugs in the modulation of neural circuits. Finally, we provide evidence about the critical role of inflammation in facilitating spinal cord neural circuit regeneration in zebrafish, an animal model with robust regenerative capacity, to provide insights into the regeneration of the mammalian central nervous system.
Original languageEnglish
Article numbertkac054
Number of pages10
JournalBurns and Trauma
Volume11
DOIs
Publication statusPublished - 2023

Open Access - Access Right Statement

© The Author(s) 2023. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Fingerprint

Dive into the research topics of 'Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications'. Together they form a unique fingerprint.

Cite this