Role of the outer membrane of Escherichia coli AG100 and Pseudomonas aeruginosa NCTC 6749 and resistance/susceptibility to monoterpenes of similar chemical structure

Shane G. Griffin, S. Grant Wyllie, Julie Markham

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Four pairs of oxygenated terpenes, with closely related chemical structures but considerably different minimum inhibitory concentration values (1) against P. l1emginosa or E. coli, showed differences in rate of cells killed over 2 h. Addition of polymyxin B nonapeptidc (PMBN) as an outer membrane permeabilising agent was found to significantly increase the initial rates and overall numbers of cells killed for all compounds. The hydrocarbon Iimonene and the ester geranyl acetate, normally inactive, were also investigated. Both compounds had little killing effect when added alone to the cells but did show all enhanced killing capacity upon the addition of PBMN.
    Original languageEnglish
    JournalJournal of Essential Oil Research
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Eschericia coli
    • carvone
    • citronellol
    • dihydrocarvone
    • geranyl acetate
    • monoterpenes

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