Rome Foundation and international neurogastroenterology and motility societies’ consensus on idiopathic gastroparesis

Jolien Schol, I. Hsuan Huang, Florencia Carbone, Luis Maria Bustos Fernandez, Guillaume Gourcerol, Vincent Ho, Geoffrey Kohn, Brian E. Lacy, Aurelio Lopez Colombo, Hiroto Miwa, Baha Moshiree, Linda Nguyen, Greg O'Grady, Kewin T.H. Siah, Vincenzo Stanghellini, Jan Tack

Research output: Contribution to journalReview articlepeer-review

Abstract

To establish a consensus on the definition and management of idiopathic gastroparesis, international experts (selected by neurogastroenterology and motility societies and initiated by the Rome Foundation) devised 144 statements using the Delphi method, with at least 80% agreement required. This consensus defined idiopathic gastroparesis as the presence of symptoms associated with delayed gastric emptying in the absence of mechanical obstruction. Nausea and vomiting were identified as cardinal symptoms. Frequently co-existing symptoms are early satiation and postprandial fullness. Diagnosis requires the presence of these symptoms alongside delayed gastric emptying, measured by a 4 h scintigraphy or gastric emptying breath test of a mixed composition meal in the absence of mechanical obstruction. Therapeutic options with proven efficacy were sparse. Dietary adjustments, nutritional support (per guidelines from the European Society for Clinical Nutrition and Metabolism for substantial weight loss or intractable vomiting), and opioid cessation were recommended by a consensus opinion. Antiemetic and prokinetic agents were also considered potentially beneficial. This consensus offers a global perspective on idiopathic gastroparesis.

Original languageEnglish
Pages (from-to)68-81
Number of pages14
JournalThe Lancet Gastroenterology and Hepatology
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2025

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© 2025 Elsevier Ltd

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