Ruthenium polypyridyl metallointercalators

Nikita Orkey; Paul Wormell; Janice Aldrich-Wright

doi:10.1007/978-3-211-99079-7_2

Ruthenium polypyridyl metallointercalators

Nikita Orkey, Paul Wormell, Janice Aldrich-Wright

School of Science

Research output: Chapter in Book / Conference Paper › Chapter

Abstract

Understanding how a molecule finds a unique binding location on DNA is one of the most significant chemical or biochemical questions. This intensive area of research, at the juction between biology and chemistry, is a challenge, as the fundamental principles by which DNA discriminates are not well understood. Investigating the biological functions of DNA necessitates probing interactions at the molecular level. As a result, there have been extensive research efforts to use transition metal complexes, particularly of ruthenium, to investigate the principles involved in DNA recognition.

Original language	English
Title of host publication	Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules
Editors	Janice R. Aldrich-Wright
Place of Publication	U.S.
Publisher	Springer
Pages	27-67
Number of pages	41
ISBN (Electronic)	9783211990797
ISBN (Print)	9783211094273
DOIs	https://doi.org/10.1007/978-3-211-99079-7_2
Publication status	Published - 2011

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10.1007/978-3-211-99079-7_2

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AB - Understanding how a molecule finds a unique binding location on DNA is one of the most significant chemical or biochemical questions. This intensive area of research, at the juction between biology and chemistry, is a challenge, as the fundamental principles by which DNA discriminates are not well understood. Investigating the biological functions of DNA necessitates probing interactions at the molecular level. As a result, there have been extensive research efforts to use transition metal complexes, particularly of ruthenium, to investigate the principles involved in DNA recognition.

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Ruthenium polypyridyl metallointercalators

Abstract

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