Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise

Muath M. Altarawneh, Aaron Petersen, Robert Smith, David M. Rouffet, Francois Billaut, Ben D. Perry, Victoria L. Wyckelsma, Antony Tobin, Michael J. McKenna

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Purpose: Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K+]a) during and after high-intensity continuous exercise (HIcont) and intermittent exercise comprising repeated, brief sprints (HIint), and on performance during HIint are unknown and were investigated. Methods: Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo. Participants cycled continuously for 5 min at 40 % V ˙ O2peak and 60 % V ˙ O2peak, then HIcont (90 s at 130 % V ˙ O2peak), 20 min recovery, and then HIint (3 sets, 5 × 4 s sprints), with 30 min recovery. Results: Plasma [K+]a increased throughout exercise and subsequently declined below baseline (P < 0.001). Plasma [K+]a was greater during HIcont than HIint (P < 0.001, HIcont 5.94 ± 0.65 vs HIint set 1, 4.71 ± 0.40 mM); the change in [K+]a from baseline (Δ[K+]a) was 2.6-fold greater during HIcont than HIint (P < 0.001). The Δ[K+] throughout the trial was less with salbutamol than placebo (P < 0.001, treatment main effect, 0.03 ± 0.67 vs 0.22 ± 0.69 mM, respectively); and remained less after correction for fluid shifts (P < 0.001). The Δ[K+] during HIcont was less after salbutamol (P < 0.05), but not during HIint. Blood lactate, plasma pH, and the work output during HIint did not differ between trials. Conclusions: Inhaled salbutamol modulated the [K+]a rise across the trial, comprising intense continuous and intermittent exercise and recovery, lowering Δ[K+] during HIcont. The limited [K+]a changes during HIint suggest that salbutamol is unlikely to influence systemic [K+] during periods of intense effort in intermittent sports.
Original languageEnglish
Pages (from-to)2389-2399
Number of pages11
JournalEuropean Journal of Applied Physiology
Volume116
Issue number45637
DOIs
Publication statusPublished - 2016

Keywords

  • albuterol
  • exercise
  • homeostasis
  • musculoskeletal system
  • potassium

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