TY - JOUR
T1 - Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise
AU - Altarawneh, Muath M.
AU - Petersen, Aaron
AU - Smith, Robert
AU - Rouffet, David M.
AU - Billaut, Francois
AU - Perry, Ben D.
AU - Wyckelsma, Victoria L.
AU - Tobin, Antony
AU - McKenna, Michael J.
N1 - Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Purpose: Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K
+]
a) during and after high-intensity continuous exercise (HI
cont) and intermittent exercise comprising repeated, brief sprints (HI
int), and on performance during HI
int are unknown and were investigated. Methods: Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo. Participants cycled continuously for 5 min at 40 % V ˙ O
2peak and 60 % V ˙ O
2peak, then HI
cont (90 s at 130 % V ˙ O
2peak), 20 min recovery, and then HI
int (3 sets, 5 × 4 s sprints), with 30 min recovery. Results: Plasma [K
+]
a increased throughout exercise and subsequently declined below baseline (P < 0.001). Plasma [K
+]
a was greater during HI
cont than HI
int (P < 0.001, HI
cont 5.94 ± 0.65 vs HI
int set 1, 4.71 ± 0.40 mM); the change in [K
+]
a from baseline (Δ[K
+]
a) was 2.6-fold greater during HI
cont than HI
int (P < 0.001). The Δ[K
+] throughout the trial was less with salbutamol than placebo (P < 0.001, treatment main effect, 0.03 ± 0.67 vs 0.22 ± 0.69 mM, respectively); and remained less after correction for fluid shifts (P < 0.001). The Δ[K
+] during HI
cont was less after salbutamol (P < 0.05), but not during HI
int. Blood lactate, plasma pH, and the work output during HI
int did not differ between trials. Conclusions: Inhaled salbutamol modulated the [K
+]
a rise across the trial, comprising intense continuous and intermittent exercise and recovery, lowering Δ[K
+] during HI
cont. The limited [K
+]
a changes during HI
int suggest that salbutamol is unlikely to influence systemic [K
+] during periods of intense effort in intermittent sports.
AB - Purpose: Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K
+]
a) during and after high-intensity continuous exercise (HI
cont) and intermittent exercise comprising repeated, brief sprints (HI
int), and on performance during HI
int are unknown and were investigated. Methods: Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo. Participants cycled continuously for 5 min at 40 % V ˙ O
2peak and 60 % V ˙ O
2peak, then HI
cont (90 s at 130 % V ˙ O
2peak), 20 min recovery, and then HI
int (3 sets, 5 × 4 s sprints), with 30 min recovery. Results: Plasma [K
+]
a increased throughout exercise and subsequently declined below baseline (P < 0.001). Plasma [K
+]
a was greater during HI
cont than HI
int (P < 0.001, HI
cont 5.94 ± 0.65 vs HI
int set 1, 4.71 ± 0.40 mM); the change in [K
+]
a from baseline (Δ[K
+]
a) was 2.6-fold greater during HI
cont than HI
int (P < 0.001). The Δ[K
+] throughout the trial was less with salbutamol than placebo (P < 0.001, treatment main effect, 0.03 ± 0.67 vs 0.22 ± 0.69 mM, respectively); and remained less after correction for fluid shifts (P < 0.001). The Δ[K
+] during HI
cont was less after salbutamol (P < 0.05), but not during HI
int. Blood lactate, plasma pH, and the work output during HI
int did not differ between trials. Conclusions: Inhaled salbutamol modulated the [K
+]
a rise across the trial, comprising intense continuous and intermittent exercise and recovery, lowering Δ[K
+] during HI
cont. The limited [K
+]
a changes during HI
int suggest that salbutamol is unlikely to influence systemic [K
+] during periods of intense effort in intermittent sports.
KW - albuterol
KW - exercise
KW - homeostasis
KW - musculoskeletal system
KW - potassium
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:44776
U2 - 10.1007/s00421-016-3481-0
DO - 10.1007/s00421-016-3481-0
M3 - Article
SN - 1439-6327
SN - 1439-6319
VL - 116
SP - 2389
EP - 2399
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 45637
ER -
