TY - BOOK
T1 - Seeing the Transplanted Mouse Heart Like Never Before: New Insights into Experimental Heart Rejection using Novel Ultrasound Applications
AU - Bishay, Ramy H.
PY - 2008
Y1 - 2008
N2 - Heart rejection is a major problem for heart transplant patients. The best strategy for understanding and preventing organ rejection is to study experimental animal models. The popular mouse model of heterotopic cardiac transplantation has been used for over three decades to help investigators understand the pathogenesis of graft rejection and in turn, how novel drugs can attenuate the immune response to transplanted organs. Also, since the genetic blueprint of mice is well-known, specific genes can be modified to study its effect on graft acceptance and tolerance. Despite the large potential for this model, little is known about the physiology, haemodynamics, and morphology of the transplanted heart and there is no method to assess objectively graft survival. This work describes in detail the use of high-frequency ultrasound for investigating the small transplanted mouse heart. For the first time, insights are made into blood flow, the effects of graft rejection, and organ survival with never before seen high-resolution images unachievable with conventional ultrasound. This work will be of significant interest to investigators, clinicians and students in the field.
AB - Heart rejection is a major problem for heart transplant patients. The best strategy for understanding and preventing organ rejection is to study experimental animal models. The popular mouse model of heterotopic cardiac transplantation has been used for over three decades to help investigators understand the pathogenesis of graft rejection and in turn, how novel drugs can attenuate the immune response to transplanted organs. Also, since the genetic blueprint of mice is well-known, specific genes can be modified to study its effect on graft acceptance and tolerance. Despite the large potential for this model, little is known about the physiology, haemodynamics, and morphology of the transplanted heart and there is no method to assess objectively graft survival. This work describes in detail the use of high-frequency ultrasound for investigating the small transplanted mouse heart. For the first time, insights are made into blood flow, the effects of graft rejection, and organ survival with never before seen high-resolution images unachievable with conventional ultrasound. This work will be of significant interest to investigators, clinicians and students in the field.
KW - graft rejection
KW - heart
KW - patients
KW - transplantation
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:45877
M3 - Authored Book
SN - 9783836487382
BT - Seeing the Transplanted Mouse Heart Like Never Before: New Insights into Experimental Heart Rejection using Novel Ultrasound Applications
PB - VDM Verlag Dr. Muller
CY - Germany
ER -