Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study

Tianruo Guo; Nigel H. Lovell; David Tsai; Perry Twyford; Shelley Fried; John W. Morley; Gregg J. Suaning; Socrates Dokos

doi:10.1109/EMBC.2014.6945023

Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study

Tianruo Guo, Nigel H. Lovell, David Tsai, Perry Twyford, Shelley Fried, John W. Morley, Gregg J. Suaning, Socrates Dokos

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

17 Citations (Scopus)

Abstract

In this study, ON and OFF retinal ganglion cell (RGC) models based on accurate biophysics and realistic representations of cell morphologies were used to understand how these cells selectively respond to high-frequency electrical stimulation (HFS). With optimized model parameters and the incorporation of detailed cell morphologies, these two models were able to closely replicate experimental ON and OFF RGC responses to epiretinal electrical stimulation. This modeling approach can be used to design electrical stimulus profiles capable of cell-specific activation, and is broadly applicable for the development of sophisticated stimulation strategies for visual prostheses.

Original language	English
Title of host publication	Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014
Publisher	IEEE
Pages	6108-6011
Number of pages	4
ISBN (Print)	9781424479276
DOIs	https://doi.org/10.1109/EMBC.2014.6945023
Publication status	Published - 2014
Event	IEEE Engineering in Medicine and Biology Society. Annual Conference - Duration: 30 Apr 2015 → …

Publication series

Name
ISSN (Print)	1557-170X

Conference

Conference	IEEE Engineering in Medicine and Biology Society. Annual Conference
Period	30/04/15 → …

Keywords

retinal ganglion cells

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10.1109/EMBC.2014.6945023

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Guo, T., Lovell, N. H., Tsai, D., Twyford, P., Fried, S., Morley, J. W., Suaning, G. J., & Dokos, S. (2014). Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study. In Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014 (pp. 6108-6011). IEEE. https://doi.org/10.1109/EMBC.2014.6945023

Guo, Tianruo ; Lovell, Nigel H. ; Tsai, David et al. / Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study. Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014. IEEE, 2014. pp. 6108-6011

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title = "Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study",

abstract = "In this study, ON and OFF retinal ganglion cell (RGC) models based on accurate biophysics and realistic representations of cell morphologies were used to understand how these cells selectively respond to high-frequency electrical stimulation (HFS). With optimized model parameters and the incorporation of detailed cell morphologies, these two models were able to closely replicate experimental ON and OFF RGC responses to epiretinal electrical stimulation. This modeling approach can be used to design electrical stimulus profiles capable of cell-specific activation, and is broadly applicable for the development of sophisticated stimulation strategies for visual prostheses.",

keywords = "retinal ganglion cells",

author = "Tianruo Guo and Lovell, {Nigel H.} and David Tsai and Perry Twyford and Shelley Fried and Morley, {John W.} and Suaning, {Gregg J.} and Socrates Dokos",

year = "2014",

doi = "10.1109/EMBC.2014.6945023",

language = "English",

isbn = "9781424479276",

publisher = "IEEE",

pages = "6108--6011",

booktitle = "Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014",

note = "IEEE Engineering in Medicine and Biology Society. Annual Conference ; Conference date: 30-04-2015",

}

Guo, T, Lovell, NH, Tsai, D, Twyford, P, Fried, S, Morley, JW, Suaning, GJ & Dokos, S 2014, Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study. in Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014. IEEE, pp. 6108-6011, IEEE Engineering in Medicine and Biology Society. Annual Conference, 30/04/15. https://doi.org/10.1109/EMBC.2014.6945023

Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study. / Guo, Tianruo; Lovell, Nigel H.; Tsai, David et al.
Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014. IEEE, 2014. p. 6108-6011.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

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T1 - Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study

AU - Guo, Tianruo

AU - Lovell, Nigel H.

AU - Tsai, David

AU - Twyford, Perry

AU - Fried, Shelley

AU - Morley, John W.

AU - Suaning, Gregg J.

AU - Dokos, Socrates

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AB - In this study, ON and OFF retinal ganglion cell (RGC) models based on accurate biophysics and realistic representations of cell morphologies were used to understand how these cells selectively respond to high-frequency electrical stimulation (HFS). With optimized model parameters and the incorporation of detailed cell morphologies, these two models were able to closely replicate experimental ON and OFF RGC responses to epiretinal electrical stimulation. This modeling approach can be used to design electrical stimulus profiles capable of cell-specific activation, and is broadly applicable for the development of sophisticated stimulation strategies for visual prostheses.

KW - retinal ganglion cells

UR - http://handle.uws.edu.au:8081/1959.7/uws:29190

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DO - 10.1109/EMBC.2014.6945023

M3 - Conference Paper

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BT - Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014

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ER -

Guo T, Lovell NH, Tsai D, Twyford P, Fried S, Morley JW et al. Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study. In Proceedings of 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Chicago, Illinois, USA, 26-30 August 2014. IEEE. 2014. p. 6108-6011 doi: 10.1109/EMBC.2014.6945023

Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation : a computational modeling study

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