Abstract
Background: Extracellular matrices (ECMs) are often used in reconstructive surgery to enhance tissue regeneration and remodeling. Sutures and staples are currently used to fix ECMs to tissue although they can be invasive devices. Other sutureless and less invasive techniques, such as photochemical tissue bonding, cannot be coupled to ECMs because of their intrinsic opacity to light. Results: We succeeded in fabricating a biocompatible and adhesive device that is based on ovine forestomach matrix (OFM) and a chitosan adhesive. The natural opacity of the OFM has been overcome by adding the adhesive into the matrix that allows for the light to effectively penetrate through it. The OFM-chitosan device is semitransparent (attenuation length~106μm) and can be photoactivated by green light to bond to tissue. This device does not require sutures or staples and guarantees a bonding strength of~23kPa. Conclusions: A new semitransparent and biocompatible bandage has been successfully fabricated and characterized for sutureless tissue bonding.
| Original language | English |
|---|---|
| Article number | 7 |
| Number of pages | 14 |
| Journal | BioMedical Engineering OnLine |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2018 |
Open Access - Access Right Statement
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Keywords
- adhesives
- biomaterials
- biopolymers
- extracellular matrix
- lasers