Sensitivity and specificity of the toe-brachial index for detecting peripheral arterial disease initial findings

Objectives - The toe-brachial index (TBI) is an alternative to the ankle-brachial index (ABI) in screening for peripheral arterial disease (PAD); however, there is limited evidence comparing their diagnostic accuracy. This study compared the diagnostic accuracy of the ABI and TBI in a population at risk of PAD. Methods - The sensitivity and specificity of the ABI and TBI were determined by color duplex sonography. Receiver operating characteristic (ROC) analysis was performed. Results - A total of 119 participants were recruited (75 male and 44 female). The sensitivity for PAD was highest for the TBI (71%; ABI, 45%), and the specificity was highest for the ABI (93%; TBI, 78%). Receiver operating characteristic analysis indicated that the TBI (ROC area, 0.77; P =.0001) had greater clinical efficacy for diagnosis of PAD than the ABI (ROC area, 0.65; P =.005). Conclusions - In specific populations, the TBI may have greater clinical efficacy than the ABI for diagnosis of PAD.