Sensitization of prostate cancer to radiation therapy : molecules and pathways to target

Mu Yao; Linda Rogers; Natalka Suchowerska; Daniel Choe; Mahmoud A. Al-Dabbas; Ramit S. Narula; J. Guy Lyons; Paul Sved; Zhong Li; Qihan Dong

doi:10.1016/j.radonc.2018.05.021

Sensitization of prostate cancer to radiation therapy : molecules and pathways to target

Mu Yao, Linda Rogers, Natalka Suchowerska, Daniel Choe, Mahmoud A. Al-Dabbas, Ramit S. Narula, J. Guy Lyons, Paul Sved, Zhong Li, Qihan Dong

Western Sydney University

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Radiation therapy is used to treat cancer by radiation-induced DNA damage. Despite the best efforts to eliminate cancer, some cancer cells survive irradiation, resulting in cancer progression or recurrence. Alteration in DNA damage repair pathways is common in cancers, resulting in modulation of their response to radiation. This article focuses on the recent findings about molecules and pathways that potentially can be targeted to sensitize prostate cancer cells to ionizing radiation, thereby achieving an improved therapeutic outcome.

Original language	English
Pages (from-to)	283-300
Number of pages	18
Journal	Radiotherapy and Oncology
Volume	128
Issue number	2
DOIs	https://doi.org/10.1016/j.radonc.2018.05.021
Publication status	Published - 2018

Keywords

DNA damage
DNA repair
cancer
prostate
radiotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.radonc.2018.05.021

Cite this

@article{c9e3edc235ed4491be751920c5a49e9e,

title = "Sensitization of prostate cancer to radiation therapy : molecules and pathways to target",

abstract = "Radiation therapy is used to treat cancer by radiation-induced DNA damage. Despite the best efforts to eliminate cancer, some cancer cells survive irradiation, resulting in cancer progression or recurrence. Alteration in DNA damage repair pathways is common in cancers, resulting in modulation of their response to radiation. This article focuses on the recent findings about molecules and pathways that potentially can be targeted to sensitize prostate cancer cells to ionizing radiation, thereby achieving an improved therapeutic outcome.",

keywords = "DNA damage, DNA repair, cancer, prostate, radiotherapy",

author = "Mu Yao and Linda Rogers and Natalka Suchowerska and Daniel Choe and Al-Dabbas, {Mahmoud A.} and Narula, {Ramit S.} and Lyons, {J. Guy} and Paul Sved and Zhong Li and Qihan Dong",

year = "2018",

doi = "10.1016/j.radonc.2018.05.021",

language = "English",

volume = "128",

pages = "283--300",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Sensitization of prostate cancer to radiation therapy : molecules and pathways to target

AU - Yao, Mu

AU - Rogers, Linda

AU - Suchowerska, Natalka

AU - Choe, Daniel

AU - Al-Dabbas, Mahmoud A.

AU - Narula, Ramit S.

AU - Lyons, J. Guy

AU - Sved, Paul

AU - Li, Zhong

AU - Dong, Qihan

PY - 2018

Y1 - 2018

N2 - Radiation therapy is used to treat cancer by radiation-induced DNA damage. Despite the best efforts to eliminate cancer, some cancer cells survive irradiation, resulting in cancer progression or recurrence. Alteration in DNA damage repair pathways is common in cancers, resulting in modulation of their response to radiation. This article focuses on the recent findings about molecules and pathways that potentially can be targeted to sensitize prostate cancer cells to ionizing radiation, thereby achieving an improved therapeutic outcome.

AB - Radiation therapy is used to treat cancer by radiation-induced DNA damage. Despite the best efforts to eliminate cancer, some cancer cells survive irradiation, resulting in cancer progression or recurrence. Alteration in DNA damage repair pathways is common in cancers, resulting in modulation of their response to radiation. This article focuses on the recent findings about molecules and pathways that potentially can be targeted to sensitize prostate cancer cells to ionizing radiation, thereby achieving an improved therapeutic outcome.

KW - DNA damage

KW - DNA repair

KW - cancer

KW - prostate

KW - radiotherapy

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:47781

U2 - 10.1016/j.radonc.2018.05.021

DO - 10.1016/j.radonc.2018.05.021

M3 - Article

SN - 0167-8140

VL - 128

SP - 283

EP - 300

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 2

ER -

Sensitization of prostate cancer to radiation therapy : molecules and pathways to target

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this