TY - JOUR
T1 - Serous ovarian and primary peritoneal cancers : a comparative analysis of clinico-pathological features, molecular subtypes and treatment outcome
AU - Gao, Bo
AU - Lindemann, Kristina
AU - Anderson, Lyndal
AU - Fereday, Sian
AU - Hung, Jillian
AU - Alsop, Kathryn
AU - Tothill, Richard W.
AU - Gebski, Val
AU - Kennedy, Catherine
AU - Balleine, Rosemary L.
AU - Australian Ovarian Cancer Study Group, null
AU - Harnett, Paul R.
AU - Bowtell, David D. L.
AU - DeFazio, Anna
PY - 2016
Y1 - 2016
N2 - Objective. Primary peritoneal cancer is rare and considered equivalent to stage III/IV ovarian cancer, but questions remain concerning its underlying biology, prognosis and optimal management. Methods. Clinico-pathological and treatment details of primary peritoneal (n = 120) and ovarian cancer (n = 635) were obtained on women recruited to the Australian Ovarian Cancer Study. Log-rank test was used to compare survival and cox proportional hazards models were fitted to obtain hazard ratios and 95% confidence intervals, both unadjusted and adjusted for age, grade, FIGO stage, residual disease and treatment with neoadjuvant chemotherapy. Molecular subtype was determined by gene expression profiling using published data. Results. Compared with advanced serous ovarian cancer, primary peritoneal cancer patients were older (mean age 65.5 vs. 60.2 years, p < 0.001), more often treated with neoadjuvant chemotherapy (38.4% vs. 11.4%, p < 0.001). Gene expression profiling classified a substantially higher proportion of primary peritoneal carcinomas as C1 (mesenchymal, reactive stromal infiltration) subtype (70.6% vs. 32.1%, p = 0.029), which was associated with lower complete surgical resection rate. Women with primary peritoneal cancer had significantly shorter progression-free (11.6 vs. 13.6 months, p = 0.007) and overall survival (31.7 vs. 39.8 months, p = 0.012). In multivariate analysis, residual disease and neoadjuvant chemotherapy were both independently associated with increased risk of progression and death.
AB - Objective. Primary peritoneal cancer is rare and considered equivalent to stage III/IV ovarian cancer, but questions remain concerning its underlying biology, prognosis and optimal management. Methods. Clinico-pathological and treatment details of primary peritoneal (n = 120) and ovarian cancer (n = 635) were obtained on women recruited to the Australian Ovarian Cancer Study. Log-rank test was used to compare survival and cox proportional hazards models were fitted to obtain hazard ratios and 95% confidence intervals, both unadjusted and adjusted for age, grade, FIGO stage, residual disease and treatment with neoadjuvant chemotherapy. Molecular subtype was determined by gene expression profiling using published data. Results. Compared with advanced serous ovarian cancer, primary peritoneal cancer patients were older (mean age 65.5 vs. 60.2 years, p < 0.001), more often treated with neoadjuvant chemotherapy (38.4% vs. 11.4%, p < 0.001). Gene expression profiling classified a substantially higher proportion of primary peritoneal carcinomas as C1 (mesenchymal, reactive stromal infiltration) subtype (70.6% vs. 32.1%, p = 0.029), which was associated with lower complete surgical resection rate. Women with primary peritoneal cancer had significantly shorter progression-free (11.6 vs. 13.6 months, p = 0.007) and overall survival (31.7 vs. 39.8 months, p = 0.012). In multivariate analysis, residual disease and neoadjuvant chemotherapy were both independently associated with increased risk of progression and death.
UR - https://hdl.handle.net/1959.7/uws:59452
U2 - 10.1016/j.ygyno.2016.06.023
DO - 10.1016/j.ygyno.2016.06.023
M3 - Article
SN - 0090-8258
VL - 142
SP - 458
EP - 464
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -